MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03625nam a2200313 i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20210307151614.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210307s2002 -usa|||| m||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-NcFUE |
| Description conventions |
rda |
| 082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Edition number |
21 |
| Classification number |
615.1 |
| Item number |
H.E.A |
| 100 10 - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hamed, ehab ahmed mamdouh |
| Relator term |
author |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Application and evaluation of extended release technology to loop diuretics / |
| Statement of responsibility, etc |
Ehab Ahmed Mamdouh Hamed . |
| 264 1# - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc |
Cincinnati, Ohio : |
| Name of publisher, distributor, etc |
University of Cincinnati, |
| Date of publication, distribution, etc |
2002 . |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
208 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
23 cm. |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Includes abstract |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.)--University of Cincinnati, 2002 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Loop diuretics offer great advantages in treating <br/> edematous states associated with congestive heart failure,<br/> liver cirrhosis and kidney failure owing to their intense <br/> diuretic effect. Evidences suggested the diuretic effect <br/> can be exaggerated by careful control of the rate at which<br/> loop diuretics are made available to the urinary tubules. <br/> If optimally designed, peroral extended release <br/> formulation can provide better utilization of the same <br/> total dose of loop diuretic, an effect of utmost <br/> importance in edematous patients with high resistance to <br/> loop diuretics. Bumetanide multiparticulate immediate and <br/> extended release formulations were developed and tested in<br/> rabbits. A novel multiple response optimization technique <br/> based on superimposing contour diagrams was developed and <br/> successfully used to optimize bumetanide release. <br/> Instability in drug release from multiparticulate <br/> formulations after storage warrants in depth investigation<br/> of different formulation and processing factors <br/> controlling drug release. Curing time, temperature, <br/> plasticizer level, coating polymer lipophilicity, and the <br/> use of hydrophilic seal coat were explored in this study. <br/> The findings proved instability in bumetanide release is <br/> attributed to drug migration into the film coat during <br/> storage. Careful selection of plasticizer level and curing<br/> conditions together with the use of hydrophilic seal coat <br/> prevented drug migration and stabilized drug release after<br/> storage. When compared to immediate release formulation in<br/> rabbits, equivalent amounts of bumetanide were excreted <br/> from both formulations yet at different rates. The slow <br/> delivery of bumetanide from the extended release <br/> formulation improved its diuretic and natriuretic <br/> efficiencies within the first day after dosing. The <br/> activation of compensatory mechanisms is thought to <br/> diminish the response to extended release bumetanide <br/> formulation within the second day. While providing <br/> comparable diuretic and saliuretic effects to that of <br/> immediate release formulation, extended release bumetanide<br/> formulation can offer the advantage of avoiding the <br/> initial, unpleasant and intense diuretic effect <br/> experienced with immediate release formulations |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pharmaceutical Sciences |
| 700 10 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
cacini,william |
| Relator term |
supervisor. |
| 700 10 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gerson, Myron |
| Relator term |
supervisor. |
| 700 10 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Desai , pankaj |
| Relator term |
supervisor. |
| 700 10 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Millard , Ronlad |
| Relator term |
supervisor. |
| 700 10 - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sakr, Adel Mohamed, |
| 9 (RLIN) |
33831 |
| Relator term |
supervisor. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |