MARC details
| 000 -LEADER |
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| fixed length control field |
03949nam a22003257i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20210310134032.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210310s2003 a|||| mb|| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-NcFUE |
| Language of cataloging |
eng |
| Modifying agency |
EG-NcFUE |
| Description conventions |
rda |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Edition number |
23 |
| Classification number |
615.19005 |
| Item number |
S.N.E |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Schulze Nahrup, Julia |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Evaluation of silicone elastomers for tablet coating / |
| Statement of responsibility, etc |
by Julia Schulze Nahrup ; Supervisor : ph.D. Adel sakr, ph.D. Hussein Al Khalidi, ph.D. James E. Mark, ph.d. Gerald B. Kasting, ph.D. Randall R. Wickett. |
| 264 #0 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2003 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
viii, 157 leaves : |
| Other physical details |
illustrations ; |
| Dimensions |
29 cm |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| Content type code |
txt |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| Media type code |
n |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| Carrier type code |
nc |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.)--University of Cincinnati, 2003 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
The objective of this project was to study the effect of modifications of endhydroxylated poly(dimethylsiloxane) (PDMS) formulations on tablet drug release. Emulsions of crosslinked endhydroxylated PDMS, a novel film-forming polymer, were characterized and investigated for their ability to be applied onto tablet cores in a spray-coating process for controlled drug release. Modifications of the crosslinking agent from the most commonly used tetraethylorthosilicate (TEOS) to the trifunctional 3-(2,3-epoxypropoxy)propyltrimethoxysilane (SIG) and a 1:1-mixture of the two crosslinker were undertaken. Addition of vermiculate clay, copolymeric substances and different channeling-agents were studied. Copolymers of methylpolysiloxane with polyoxyethylene (DC193 and DC5324) or dimethyl, methyl (polyoxyethylene) (DCQ2-5220) as well as poly (acrylamide-co-acrylic acid) were used. Lactose, microcrystalline cellulose (MCC) and polyethyleneglycol 8000 (PEG) were the channeling-agents applied. A change in molecular weight of the PDMS was analyzed. Effects on dispersion properties were characterized by particle size distribution, viscosity and visual observation of phase-separation. Mechanical properties of resulting cast and sprayed films were studied to determine applicability in a pan-coating process. Release of Hydrochlorothiazide (marker-drug) was studied from tablets coated in a lab-size conventional coating pan. Dispersions were found suitable for a spray-coating process. Only the formulation with acrylic-copolymer addition was unstable as phase separation occurred. Preparation of free films showed that methylpolysiloxane-copolymers negatively affected the mechanical properties so that coating onto tablet cores was not possible. Tablets coated with formulations crosslinked using the 1:1-mixture of SIG/TEOS and containing polyethyleneglycol were most suitable to control drug release, at 5% coating weight. Constant release rates were achieved for formulations with up to 25% (w/w of PDMS) PEG; higher amounts resulted in a non-linear release pattern. Upon adding 50% PEG, a drug release of 62% over 24 hours could be achieved. Formulations containing 25 and 50% (w/w of PDMS) PEG were stable for at least 3 months when tested according to ICH-guidelines. In comparison with Eudragit NE (copolymeric product of 2:1 ethylacrylate / methylmethacrylate) PDMS-formulations showed similar mechanical and improved spray-application properties. Addition of channeling agents was necessary for both products to achieve drug release. The effect of polyethyleneglycol was greater on formulations based on PDMS than for Eudragit NE. |
| 610 20 - SUBJECT ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
University of Cincinnati |
| General subdivision |
Theses. Ph.D. (Pharmaceutical Sciences) 2003. |
| 9 (RLIN) |
33866 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pharmaceutical technology |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pharmaceutical industry |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Al Khalidi, Hussein, |
| Relator term |
supervisor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sakr, Adel Mohamed, |
| Relator term |
supervisor. |
| 9 (RLIN) |
33831 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mark, James E., |
| Relator term |
supervisor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kasting, Gerald B., |
| Relator term |
supervisor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wickett, Randall R., |
| Relator term |
supervisor. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |