MARC details
| 000 -LEADER |
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| fixed length control field |
03670nam a22003257i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20231211140427.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211026s2021 ua a|||| bm|| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-NcFUE |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
22 |
| Classification number |
616.99 |
| Item number |
E.E.P |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
33889 |
| Personal name |
El Sawaf, Engie Samir, |
| Relator term |
author. |
| 245 14 - TITLE STATEMENT |
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| Title |
The possible impact of vitamin D3 on peripheral neuropathy induced by diabetes in a rat model / |
| Statement of responsibility, etc |
by Engie Samir El Sawaf (Teaching Assistant Pharmacology & Toxicology & Biochemistry department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt) |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التأثير المحتمل لفتيامين د 3 في التهاب الأعصاب الطرفية المصاحب لمرض السكري المحدث في الجزان |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
1 online resource (156 pages, 4 pages) : |
| Other physical details |
illustrations (some color) |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
computer |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
online resource |
| 500 ## - GENERAL NOTE |
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| General note |
Supervision of Dr. Dalaal Moustafa Abdallah (Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University), Dr. Samira Saleh Mostafa (Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University), Dr. Hanan Salah El-Din El-Abhar (Professor & Head of Pharmacology, Toxicology & Biochemistry department, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt (FUE)<br/> |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.)-Cairo university, Faculty of pharmacy, Department of Pharmacology and Toxicology, 2021. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references. |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc |
Vitamin D and rosuvastatin are two well-known drugs that mediate beneficial effects in type 2 diabetes (T2D) complications, however, their anti-neuropathic potential is still debatable. Hence, we studied the possible neurotherapeutic effect & the possible underling mechanisms. Additionally, evaluating the merit of their combination using a high fat fructose diet/streptozotocin (HFFD/STZ) T2D model. In addition to the control group, rats with T2D-associated neuropathy (6 weeks post STZ) were allocated into untreated and treated with vitamin D (cholecalciferol, 3500 IU/kg/week), rosuvastatin (10 mg/kg/day), or both. After 2 months of treatment, the therapeutic effect on small/large nerves was investigated using tail flick test, electrophysiological examination and histological evaluation, which documented that long-term use of vitamin D and/or rosuvastatin regenerated neuronal function and architecture of the sciatic nerve. These treatment regimens also decreased neuronal inflammation and apoptosis verified by inhibiting neuron content of TNF- and IL-18, as well as caspase-3 activity, while augmenting Bcl-2 content. On the molecular level, vitamin D and rosuvastatin abated the protein expression of NICD1, Wnt-10, β-catenin and TGF-β, while augmented the sciatic nerve content of SMAD7. These effects were associated with an upturn in the neuronal mitochondrial function (NRF-1, TFAM, mtDNA, and ATP). In conclusion, vitamin D and/or rosuvastatin abridged diabetes-induced neuropathy via turning off Notch1, Wnt-10/β-catenin and modulating TGF-β/SMAD7 signaling along with enhancing mitochondrial function, effects that lessened neuronal degeneration, demyelination and fibrosis.<br/> |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Rats |
| General subdivision |
Diseases |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Diabetes |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Vitamin D |
| General subdivision |
Therapeutic use |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Materials specified |
DSpace electronic resource |
| Uniform Resource Identifier |
<a href="http://repository.fue.edu.eg/xmlui/handle/123456789/5795">http://repository.fue.edu.eg/xmlui/handle/123456789/5795</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
| Source of classification or shelving scheme |
Dewey Decimal Classification |