MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04093ntm a2200313 i 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
12102116 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20240922101356.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150118s2021 ua a f bm 000 0 eng | |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-EULC |
| Transcribing agency |
EG-EULC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
615.19 |
| Item number |
E.N.P |
| Edition number |
22 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Salem, Mohamed Ahmed Mahmoud |
| 9 (RLIN) |
33910 |
| Relator term |
author |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Possible modulatory effect of tadalafil and bergapten on experimentally induced cognitive impairment in mice / |
| Statement of responsibility, etc |
Mohamed Ahmed Mahmoud Salem (B. Pharm. 2016), Teaching Assistant of Pharmacology, Toxicology, and Biochemistry, Faculty of Pharmacy, Future University in Egypt (FUE), Supervision of Dr. Nesrine Salah El Dine El Sayed, Professor and Head of Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Dr. Suzan Mohamed Mansour, Associate Professor of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt (FUE)<br/><br/> |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير فاعلية التطبيع المحتمل لعقاري التادالافيل والبيرجابتين لاعتلال الادراك المستحدث تجريبيا في الفئران |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
139 pages, 4 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
21 cm |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Supervision of Dr. Nesrine Salah El Dine El Sayed, Professor and Head of Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Dr. Suzan Mohamed Mansour, Associate Professor of Pharmacology, Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt (FUE) |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.)-Cairo University, Faculty of Pharmacy, Department of Pharmacology & Toxicology, 2021. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc |
Sporadic Alzheimer’s disease (SAD) is a slowly progressive <br/>neurodegenerative disorder characterized by deposition of amyloid beta (Aβ) <br/>plaques, tau protein aggregation, impaired insulin signaling, and <br/>neuroinflammation. This study aimed to investigate the neuroprotective <br/>potential of tadalafil (TAD) and bergapten (BG) in SAD-induced cognitive <br/>impairment in mice. SAD was induced by a single intracerebroventricular <br/>injection of streptozotocin (STZ) (3 mg/kg). TAD or BG was administered <br/>intraperitoneally at doses of 20 and 25 mg/kg, respectively, 5 hours after STZ <br/>injection for 21 consecutive days. TAD and BG conceivably attenuated STZinduced hippocampal insult, preserved neuronal integrity, and improved <br/>cognitive function in the Morris water maze and object recognition tests <br/>paralleled by reduced Aβ expression and phosphorylation of tau. Moreover, <br/>TAD and BG enhanced the protein expression of pAkt, pGSK-3β, beclin-1, <br/>and methylated protein phosphatase 2A (PP2A) and cyclin D1 gene expression <br/>and raised brain-derived neurotrophic factor immunoreactivity. In addition, <br/>both drugs boosted the hippocampal levels of cyclic guanosine <br/>monophosphate (cGMP), protein kinase G (PKG), WNT3A, and adenosine <br/>monophosphate-activated protein kinase coupled by reduced protein <br/>expression of β-catenin and mammalian target of rapamycin (mTOR). TAD <br/>and BG also halted neuroinflammation as evidenced by reduced IL-23 and IL27 levels and NF-κB protein expression. However, the effects of BG were <br/>superior than that of TAD on the restoration of the brain histological profile.<br/>In conclusion, this study offers novel insights on the neuroprotective effects <br/>of TAD or BG in the management of AD as evidenced by the improved <br/>cognitive function and histopathological architecture. This could be attributed <br/>to modulation of the crosstalk among Akt/GSK-3β, PP2A, mTOR/autophagy, <br/>cGMP/PKG, and Wnt/β-catenin signaling cascades and mitigation of <br/>neuroinflammation.<br/> |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
pharmacology |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
DSpace electronic resources |
| Uniform Resource Identifier |
<a href="http://repository.fue.edu.eg/handle/123456789/6045">http://repository.fue.edu.eg/handle/123456789/6045</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
| Source of classification or shelving scheme |
Dewey Decimal Classification |