MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04047nam a22003617i 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220407s2022 ua a|||f bm|| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-EULC |
| Transcribing agency |
EG-EULC |
| Modifying agency |
EG-EULC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
23 |
| Classification number |
616.83 |
| Item number |
A.D.C |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abou El fadl, Dina Khaled Mohamed |
| Relator term |
author. |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A Clinical study on the impact of docosahexaenoic acid on the prevention of necrotizing enterocolitis in preterm neonates / |
| Statement of responsibility, etc |
By Dina Khaled Mohamed Abou El fadl ; supervisors : prof. Nagwa Ali Saberi, prof. Ebtissam Abdel Ghaffar Darweesh, Dr. Marwa Adel Ahmed, Dr. Yasmin Aly Farid. |
| 246 35 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة إكلينيكية عن تأثير حمض الدوكوساهيكسانويك فى الوقاية من إلتهاب الامعاء والقولون الناخر فى المبتسرين |
| 264 #0 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2022. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
134 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
24 cm |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| Content type code |
txt |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| Media type code |
n |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| Carrier type code |
nc |
| 500 ## - GENERAL NOTE |
|---|
| General note |
supervisors : prof. Nagwa Ali Saberi, prof. Ebtissam Abdel Ghaffar Darweesh, Dr. Marwa Adel Ahmed, Dr. Yasmin Aly Farid. |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.)-Ain Shams university, Faculty of pharmacy, Department of Pharmacy practice and clinical pharmacy, 2022. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references (95-123 p.) |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc |
Preterm neonates have under-developed immune-regulatory system; consequently, there is a risk for developing chronic inflammation. Necrotizing enterocolitis (NEC) is an acute devastating neonatal intestinal inflammatory disorder. Due to the obscure multifactorial etiology, early diagnosis and effective treatment of NEC are limited. Consequently, effective strategies in the prevention of NEC, including nutritional approaches, are critically needed. The current study was conducted to assess the potential immunomodulatory effect of Docosahexaenoic Acid (DHA) supplementation in preterm neonates at neonatal intensive care unit (NICU) and subsequently its effect on preventing or reducing NEC incidence. This was a prospective randomized controlled study. A total of 67 neonates, with gestational age equal or less than 32 weeks at birth and weight less than or equal 1500 g, were randomly assigned to either DHA group or the control group. Modified Bell’s staging criteria for NEC was used as an objective tool for diagnosis and staging of NEC. Levels of Interleukin 1 beta (IL-1β) were measured at baseline and after 10 days. Mortality and NICU length of stay (LOS) were also monitored. Thirty neonates of each group completed the study. A statistically significant difference was observed between the two groups regarding diagnosis and staging of NEC (p = 0.0001). There was also a statistically significant difference between DHA group 22(73.3), 95% CI [55.9, 86.5] and the control group 8 (26.7), 95% CI [13.5, 44.1] in the percentage change in IL-1β levels (p = 0.0001). A statistically significant association was found between IL and 1 β change and NEC diagnosis (p = 0.001). NICU LOS was significantly lower among DHA group 21.63 ± 6.67 compared to the control group 25.07 ± 4.67 (p = 0.025). Mortality n (%) among the control group 4 (11.8) was higher than DHA group 3 (9.1), however, no significant difference was detected (p = 1.0). Findings of this study suggest that enteral DHA supplementation can reduce NEC incidence in preterm neonates through its immunoregulatory effect that modulates production of regulatory cytokines. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Docosahexaenoic acid. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Docosahexaenoic Acids. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Health aspects. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
physiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
33919 |
| Personal name |
Saberi, Nagwa Ali |
| Relator term |
supervisor |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
33920 |
| Personal name |
Darweesh, Ebtissam Abdel Ghaffar |
| Relator term |
supervisor |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
33921 |
| Personal name |
Ahmed, Marwa Adel |
| Relator term |
supervisor |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
33922 |
| Personal name |
Farid, Yasmin Aly |
| Relator term |
supervisor |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
DSpace electronic resources |
| Uniform Resource Identifier |
http://repository.fue.edu.eg/xmlui/handle/123456789/6048 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Item type |
Thesis |