MARC details
| 000 -LEADER |
|---|
| fixed length control field |
04180ntm a2200301 i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20230110112541.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150118s2022 ua a f bm 000 0 eng | |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-EULC |
| Transcribing agency |
EG-EULC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
572 |
| Item number |
A.M.S |
| Edition number |
22 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ali, Mohamed Salah Attia Radwan, |
| 9 (RLIN) |
33980 |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Studying the possible role of some long noncoding RNAs in multiple sclerosis / |
| Statement of responsibility, etc |
By Mohamed Salah Attia Radwan Ali, Teaching assistant, Biochemistry Section, Faculty of Pharmacy, Future University in Egypt; Supervision of Prof. Dr. Maha M. El-Sawalhi, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Prof. Dr. Shohda A. El-Maraghy, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Ass. Prof. Dr. Hebatollah Atef Ewida, Associate Professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt. |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة الدور المحتمل لبعض الأحماض النووية الريبوزية الطويلة غير المشفرة في التصلب المتعدد |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2022. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
viii, 138 pages, 4 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
22 cm |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Supervision of Prof. Dr. Maha M. El-Sawalhi, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Prof. Dr. Shohda A. El-Maraghy, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Ass. Prof. Dr. Hebatollah Atef Ewida, Associate Professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.)-Future University in Egypt, Faculty of pharmacy, Department of Biochemistry, 2022. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc |
Multiple sclerosis (MS) is the primary cause of non-traumatic neurological disability in young adults. Relapsing-remitting MS (RRMS) is the most prevalent MS subtype. Ample evidence indicated that long noncoding RNAs (lncRNAs) are crucial players in autoimmune and inflammatory disorders. Despite the rapidly increasing data concerning MS-related lncRNAs, the impact of others remains to be explored. This study investigated for the first time the expression profiles of lnc-EGFR, SNHG1, and lincRNA-Cox2 in Egyptian patients with RRMS during active relapses and in remission. Besides, the expression of FOXP3, a master transcription factor for T-regulatory cells, and the NLRP3 inflammasome-related genes were determined. Relations between these parameters and MS activity and annualized relapse rate (ARR) were evaluated. Expression of the three lncRNAs, FOXP3, NLRP3, ASC, and caspase-1 along with serum TGF-β1and IL-1β levels were measured in 70 RRMS patients (35 during relapse and 35 in remission) and 30 healthy controls. RRMS patients showed significant downregulation of lnc-EGFR and FOXP3 together with dramatic upregulation of SNHG1, lincRNA-Cox2, NLRP3, ASC and caspase-1 expression compared to controls. Lower serum TGF-β1 and elevated IL-1β levels were observed in RRMS patients. Notably, patients during relapses displayed more significant alterations than those in remission. Lnc-EGFR was positively correlated with FOXP3 and TGF-β1, and negatively correlated with ARR, SNHG1, lincRNA-Cox2 and NLRP3 inflammasome-components. Meanwhile, SNHG1 and lincRNA-Cox2 were positively correlated with ARR, NLRP3, ASC, caspase-1 and IL-1β. Excellent diagnostic performance for lnc-EGFR, FOXP3 and TGF-β1 was demonstrated, while all the biomarkers exhibited strong prognostic potential for predicting relapses. Finally, the differential expression of lnc-EGFR, SNHG1, and lincRNA-Cox2 in RRMS patients especially during relapses suggests their involvement in RRMS pathogenesis and activity. Moreover, correlation between their expression and ARR implies relation to disease progression. Our findings also highlight their promising roles as biomarkers for RRMS. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Biochemistry |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
DSpace electronic resources |
| Uniform Resource Identifier |
<a href="http://repository.fue.edu.eg/handle/123456789/6248">http://repository.fue.edu.eg/handle/123456789/6248</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
| Source of classification or shelving scheme |
Dewey Decimal Classification |