MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03656ntm a2200313 i 4500 |
| 001 - CONTROL NUMBER |
|---|
| control field |
12102116 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20230430090640.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150118s2023 ua a f bm 000 0 eng | |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-EULC |
| Transcribing agency |
EG-EULC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
574.192 |
| Item number |
Z.A.E |
| Edition number |
22 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Zayed, Aya Ahmed Kamal, |
| 9 (RLIN) |
33986 |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of some long non coding RNAs expression and their relation to GABAergic dysfunction in epilepsy in Egyptian patients / |
| Statement of responsibility, etc |
Submitted by Aya Ahmed Kamal Zayed, (Bachelor degree of Pharmacy (2014), Teaching Assistant, Biochemistry Section, Faculty of Pharmacy, Future University in Egypt (FUE)); Supervision of Prof. Dr.Amira A. Shaheen, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Prof. Dr. Hebatallah A.Darwish, Professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Mae M. Selim, Associate professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقييم التعبير الجيني لبعض الأحماض النووية الريبوزية غير المشفرة وارتباطها بالخلل الوظيفي للجابا في مرض الصرع لدى المرضى المصريين |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc |
2023. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
vii, 89 pages, 4 pages : |
| Other physical details |
illustrations (some color) ; |
| Dimensions |
22 cm |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
|---|
| Source |
rdacarrier |
| Carrier type term |
volume |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Supervision of Prof. Dr.Amira A. Shaheen, Professor of Biochemistry, Faculty of Pharmacy, Cairo University, Prof. Dr. Hebatallah A.Darwish, Professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt, Dr. Mae M. Selim, Associate professor of Biochemistry, Faculty of Pharmacy, Future University in Egypt |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.)-Cairo University, Faculty of pharmacy, Department of Biochemistry, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references. |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc |
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures. Lately, long noncoding RNAs (lncRNAs) have been increasingly appreciated as regulators of epilepsy-related processes, however, their functional role in its pathogenesis is still to be explored. This study investigated the expression levels of lncRNAs; BDNF-AS and 17A in the sera of Egyptian patients with idiopathic generalized and symptomatic focal epilepsy and correlated their levels with brain-derived neurotrophic factor (BDNF), phosphorylated cAMP reaction element-binding protein (p-CREB), gamma- aminobutyric acid (GABA) and glutamate, to underline their related molecular mechanism. A total of 70 epileptic patients were divided into two clinical types, besides 30 healthy controls of matched age and sex. The expression levels of both lncRNAs were markedly upregulated in epileptic groups versus healthy control with predominance in the symptomatic focal one. Epileptic patients showed significantly lower levels of BDNF, p-CREB, GABA along with significant increases of glutamate levels and glutamate/ GABA ratio, especially in symptomatic focal versus idiopathic generalized epileptic ones. The obtained data raised the possibility that these lncRNAs might be involved in the pathogenesis of epilepsy via inhibition of GABA/p-CREB/BDNF pathway. The study shed light on the putative role of these lncRNAs in better diagnosis of epilepsy, particularly symptomatic focal epilepsy. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Biochemistry |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
DSpace electronic resources |
| Uniform Resource Identifier |
<a href="http://repository.fue.edu.eg/xmlui/handle/123456789/5779">http://repository.fue.edu.eg/xmlui/handle/123456789/5779</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Thesis |
| Source of classification or shelving scheme |
Dewey Decimal Classification |