MARC details
| 000 -LEADER |
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| fixed length control field |
04794ntm a2200397 i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
12102116 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20240721160322.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150118s2024 ua a f bm 000 0 eng | |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-EULC |
| Transcribing agency |
EG-EULC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract/overprinted title or subtitle |
ara |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
22 |
| Classification number |
615.321 |
| Item number |
S.S.C |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Sarah Mohamed Osama Saeed |
| Relator term |
author |
| 245 10 - TITLE STATEMENT |
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| Title |
Chemical and Biological Evaluation of Bioactive Secondary Metabolites Isolated from Endophytic Fungi of Hedera helix L. Plant / |
| Statement of responsibility, etc |
By Sarah Mohamed Osama Saeed; supervisor Prof. Dr. Moshera M. El-Sherei Professor of Pharmacognosy Faculty of Pharmacy Cairo University, Prof. Dr. Osama M. Salama Late Professor of Pharmacognosy Vice President Future University in Egypt, Prof. Dr. Osama M. Salama Late Professor of Pharmacognosy Vice President Future University in Egypt, Assoc. Prof. Marwa M. Rafaat Associate Professor of Microbiology Faculty of Pharmacy Future University in Egypt, Dr. Mokhtar M. Bishr Technical Director, Plant Manager of Arab Co. For Pharmaceuticals & Medicinal Plants (Mepaco). |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
تقييم كيميائي وبيولوجي للمركبات المفصولة من الفطريات الداخلية لنبات هيدرا هيليكس ل. |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Date of publication, distribution, etc |
2024 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
88 pages, III pages : |
| Other physical details |
illustrations ; |
| Dimensions |
24 cm |
| 336 ## - CONTENT TYPE |
|---|
| Source |
rdacontent |
| Content type term |
text |
| 337 ## - MEDIA TYPE |
|---|
| Source |
rdamedia |
| Media type term |
unmediated |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| 500 ## - GENERAL NOTE |
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| General note |
Under the Supervision of Prof. Dr. Moshera M. El-Sherei Professor of harmacognosy Faculty of Pharmacy Cairo University Prof. Dr. Osama M. Salama Late Professor of Pharmacognosy Vice President Future University in Egypt Prof. Dr. Dalia A. M. Al-Mahdy Professor of Pharmacognosy Faculty of Pharmacy Cairo University Pharmacognosy Department Faculty of Pharmacy Cairo University Egypt 2024 Assoc. Prof. Marwa M. Rafaat Associate Professor of Microbiology Faculty of Pharmacy Future University in Egypt Dr. Mokhtar M. Bishr Technical Director, Plant Manager of Arab Co. For Pharmaceuticals & Medicinal Plants (Mepaco) |
| 500 ## - GENERAL NOTE |
|---|
| General note |
For the Degree of Doctor of Philosophy in Pharmaceutical Sciences (Pharmacognosy). |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Master Degree of Pharmacognosy - Faculty of Pharmacy- Cairo University 2019. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references. |
| 520 3# - SUMMARY, ETC. |
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| Summary, etc |
The demand for new and useful compounds to help and relieve people in<br/>all aspects of their lives is constantly increasing. Drug resistance in bacteria, the<br/>emergence of life-threating viruses, the enormous spreading of cancer, recurring<br/>disease problems in organ transplant recipients, and the massive increase in the<br/>incidence of fungal infections in the world's population all highlight our inability<br/>to deal with those medical issues. Owing to all these facts, there is a need to<br/>explore new and useful bioactive compounds to provide assistance and relief in<br/>all aspects of human conditions. Thus, the aim of this study was to screen the<br/>well-known medicinal plant Hedera helix L. for its endophytic fungi and to<br/>investigate their potential antimicrobial activities as well as their L-asparaginase<br/>production ability. Bio-guided fractionation approach was conducted to isolate<br/>the pure compounds from the most active fungal fraction. Out of total 6 different<br/>isolated endophytic fungal strains, only Aspergillus cejpii showed the highest<br/>activity against all tested microbial strains. The bio-guided fractionation of the<br/>DCM: MeOH fraction led to the isolation of spiculisporic acid. The compound<br/>showed good antimicrobial activities with minimum inhibitory concentration<br/>(MIC) values ranging from 3.9-31.25 μg/mL against all tested strains.<br/>Concerning the L-asparaginase enzyme production, Fusarium solani<br/>showed highest L-ASNase production (22.76 IU/ml/hr) and thus was selected for<br/>additional characterization and optimization studies on maximizing its<br/>productivity in addition to evaluating its subsequent cytotoxicity towards acute<br/>monocytic leukemia (THP1) and Human Skin Fibroblast (HSF) cell lines where<br/>it revealed promising cytotoxic activity against acute monocytic leukemia with<br/>IC50 = 3.66 μg/ml with low cytotoxicity against tested normal Human Skin<br/>Fibroblast cell line. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
Text in English, abstracts in English and Arabic. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pharmacognosy |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Medicinal plants |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Prof. Dr. El-Sherei, Moshera M. |
| Relator term |
supervisor |
| 9 (RLIN) |
34078 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Prof. Dr. Salama, Osama M. |
| Relator term |
supervisor |
| 9 (RLIN) |
34079 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Prof. Dr. Al-Mahdy, Dalia A. M. |
| Relator term |
supervisor |
| 9 (RLIN) |
34080 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Assoc. Prof. Rafaat, Marwa M. |
| Relator term |
supervisor |
| 9 (RLIN) |
34081 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dr. Bishr, Mokhtar M. |
| Relator term |
supervisor |
| 9 (RLIN) |
34082 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
DSpace electronic resource |
| Uniform Resource Identifier |
http://repository.fue.edu.eg/xmlui/handle/123456789/6333 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Item type |
Thesis |