| Formatted contents note |
Machine generated contents note: Section 1: Groundwork, 1 -- 1 The Excitement of Developmental Biology, 3 -- Where the subject came from, 3 -- Central position in biology, 3 -- Impact on society, 4 -- Future impact, 4 -- 2 General Problems of Development, 6 -- Nuclear totipotency, cloning of animals, 7 -- 3 Key Molecular Components, 10 -- Genes, 10 -- Signalling systems, 13 -- Cytoskeleton, 16 -- Cell adhesion molecules, 18 -- Appendix,19 -- Transcription factor families, 19 -- Inducing factor families, 20 -- Cell adhesion molecules, 24 -- Extracellular matrix components, 25 -- 4 Common Features of Development, 27 -- Gametogenesis, 27 -- Fertilization, 30 -- Early development, 30 -- Morphogenetic processes, 35 -- Evolution of developmental mechanisms,41 -- 5 Developmental Genetics, 48 -- Developmental mutants, 48 -- Screening for mutants, 53 -- Cloning of genes, 55 -- Transgenesis, 55 -- Limitations of developmental genetics, 57 -- 6 Experimental Embryology, 60 -- Normal development, 60 -- Developmental commitment, 63 -- Acquisition of commitment, 66 -- Homeotic genes, 68 -- 7 Techniques for the Study of Development, 73 -- Microscopy, 73 -- Study of gene expression by biochemical methods, 76 -- In situ methods, 79 -- Microinjection, 81 -- Cell-labelling methods, 83 -- Reporter genes, 84 -- Section 2: Major Model Organisms, 87 -- 8 Model Organisms, 89 -- Availability and cost, 89 -- Access and micromanipulation, 90 -- Genetics and genome maps, 90 -- Relevance, 91 -- 9 Xenopus,93 -- Oogenesis, maturation, fertilization, 93 -- Embryonic development, 94 -- Experimental methods, 100 -- Regional specification, 103 -- Inductive interactions, 108 -- 10 TheZebrafish, 116 -- Normal development, 116 -- Mutagenesis, 117 -- Regional specification, 120 -- 11 The Chick, 122 -- Normal development, 123 -- Regional specification of the early embryo, 129 -- Description of organogenesis in the chick, 131 -- 12 The Mouse, 140 -- Normal development, 140 -- Technology of mouse development, 149 -- Regional specification in development, 158 -- Other topics in mouse development, 162 -- 13 Drosophila,165 -- Insects, 165 -- Normal development, 166 -- Drosophila developmental genetics, 169 -- Overview of the developmental program, 173 -- The dorsoventral pattern, 174 -- The anteroposterior system, 178 -- 14 Caenorhabditis elegans, 191 -- Normal development, 191 -- Regional specification in the embryo, 193 -- Analysis of postembryonic development, 198 -- Programmed cell death, 200 -- Section 3: Organogenesis and Regeneration, 205 -- 15 Tissues, 207 -- Epithelial tissues, 207 -- Connective tissues, 207 -- Muscle, 209 -- Neural tissues, 209 -- Blood and blood vessels, 209 -- 16 Development of the Nervous System, 212 -- Overall structure and cell types, 212 -- Anteroposterior patterning of the neural plate, 216 -- Dorsoventral patterning of the neural tube, 219 -- Neurogenesis and gliogenesis, 220 -- The neural crest, 224 -- Development of neuronal connectivity 227 -- 17 Development of Mesodermal Organs, 236 -- Somitogenesis, 236 -- The kidney, 242 -- Gonadal development, 245 -- Limb development, 250 -- 18 Drosophila Imaginal Discs, 262 -- Metamorphosis, 262 -- Genetic study of larval development, 262 -- Mitotic recombination, 264 -- Disc development, 268 -- Regional patterning of the wing disc, 272 -- Regional patterning of the leg disc, 275 -- 19 Stem Cells and Tissue Growth, 278 -- Size and proportion, 278 -- Renewal tissues, 279 -- Growth in stature, 288 -- Postnatal disorders of growth and differentiation, 291 -- Cancer, 291 -- 20 Regeneration of Missing Parts, 296 -- Distribution of regenerative capacity, 296 -- Planarian regeneration, 297 -- Vertebrate limb regeneration, 300. |