MARC details
| 000 -LEADER |
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09083cam a22003734i 4500 |
| 001 - CONTROL NUMBER |
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63125814 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20201007132910.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
060119r2011 ii a b 001 0 eng |
| 010 ## - LIBRARY OF CONGRESS CONTROL NUMBER |
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| LC control number |
2006000882 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9788126528547 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
DLC |
| Transcribing agency |
DLC |
| Modifying agency |
YDX |
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BAKER |
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IXA |
| Description conventions |
rda |
| 082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.321 |
| Edition number |
22 |
| Item number |
M |
| 245 00 - TITLE STATEMENT |
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| Title |
Medicinal chemistry of bioactive natural products / |
| Statement of responsibility, etc |
edited by Xiao-Tian Liang, Wei-Shuo Fang. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Date of publication, distribution, etc |
c2011. |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
New Delhi : |
| Name of publisher, distributor, etc |
J. Wiley, |
| Date of publication, distribution, etc |
[2011]. |
| 264 #4 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Date of publication, distribution, etc |
©2011 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xix, 460 pages : |
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illustrations ; |
| Dimensions |
25 cm |
| 336 ## - CONTENT TYPE |
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rdacontent |
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text |
| 337 ## - MEDIA TYPE |
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rdamedia |
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unmediated |
| 338 ## - CARRIER TYPE |
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rdacarrier |
| Carrier type term |
volume |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Chapter 1 The Chemistry and Biology of Epothilones?Lead Structures for the Discovery of Improved Microtubule inhibitors<br/>Karl-Heinz Altmann<br/>1. Introduction<br/>2. Biological effects of Epo B<br/> In vitro activity<br/> In vivo antitumor activity <br/>3. Epothilone analogs and SAR studies <br/> Lactam-based analogs <br/> Modifications in th eC9-C11 regions <br/> Modifications of the epoxide moiety <br/> C-26 modifications<br/> Aza-epothilones <br/>4. Pharmacophore modelling and conformational studies<br/>5. Epothilone analogs in clinical development <br/>6. Conclusions<br/>7. Acknowledgement <br/>8. References<br/>Chapter 2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives <br/>Roderich D. Suessmuth<br/>1. Introduction<br/>2. Classification of Glycopeptide Antibiotics<br/>3. Mode of Action<br/>4. Glycopeptide resistance<br/>5. Biosynthesis<br/>6. Total synthesis<br/>7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis<br/>8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies<br/>8.1 Modifications of Glycopeptide Antibiotics<br/> 8.2 Rational Concepts for the Design of Novel Glycopeptides<br/> 8.3 Conclusions<br/>9. References |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Chapter 3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogues<br/>Wei-shuo Fang, Qi-Cheng Fang, Xiao-tian Liang<br/>1. Discovery and research and development of Taxol?<br/>2. Paclitaxel analogues active against sensitive tumor cells<br/> 2.1 C-13 side chain<br/> 2.2 A ring and its substitutions<br/> 2.3 B ring and its substitutions<br/> 2.4 C ring and its substitutions<br/> 2.5 D ring<br/> 2.6 Macrocyclic analogues<br/> 2.7 Miscellaneous<br/>3. Exploration on mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore<br/> 3.1 Biochemical mechanism of paclitaxel related to tubulin binding<br/> 3.2 Identification of bioactive conformations and quest for a pharmacophore for paclitaxel<br/>4. Natural taxanes and semi-synthetic taxoids overcoming multi-drug resistance (MDR)<br/> 4.1 Structure modified taxoids with better activity towards MDR tumors<br/> 4.2 Non-paclitaxel type taxoids with MDR reversal activities<br/> 4.3 Factors contributing to the resistance to paclitaxel<br/>5 Design, synthesis and pharmacological activity of prodrugs of paclitaxel<br/> 5.1 Prodrugs prepared to improve water solubility<br/> 5.2 Prodrugs designed for enhancing specificity<br/>6. Other biological actions of paclitaxel--Apoptosis and immune stimulation<br/>7. New anti-microtubule molecules mimicking action of paclitaxel<br/>8. Conclusion<br/>Chapter 4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer?s Disease<br/>Da-Yuan Zhu, Chang-Heng Tan, Yi-Ming Li<br/>1. Introduction <br/> 1.1 Powerful AChEI originated from TCM<br/> 1.2 Alzheimer?s disease<br/>2. Profiles of HA <br/> 2.1 Discovery of HA<br/> 2.2 Physical Appearance<br/>3. Plant resources<br/>4. Pharmacology<br/> 4.1 Effects on Cholinesterase Activity<br/> 4.2 Effects on Learning and Memory<br/> 4.3 Effects in Protection of Neuronal Cells<br/> 4.4 Toxicology <br/> 4.5 Effects on Miscellaneous Targets<br/>5. Clinical trials <br/>6. Synthesis of HA and its analogues<br/> 6.1 Synthesis of racemic HA<br/> 6.2 Synthesis of Optically Pure (-)-HA<br/> 6.3 Studies on the Structure-Activity Relationship<br/>7. Structural biology <br/> 7.1 Interaction between HA and AChE<br/> 7.2 Structure-Based HA Analogs Design<br/>8. ZT-1: New generation of HA ACHEI <br/> 8.1 Pharmacology<br/> 8.2 Toxicology<br/> 8.3 Pharmacokinetics<br/> 8.4 Clinical Trials |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Chapter 5 Qinghaosu (artemisinin)---A Fantastic Antimalarial Drug from a Traditional Chinese Medicine<br/>Ying Li, Hao Huang, and Yu-Lin Wu<br/>1. Introduction<br/>2. Qinghaosu and qinghao (Artemisia annua L. composites)<br/> 2.1. Discovery and structure determination of qinghaosu<br/> 2.2. The phytochemistry of qinghao and other natural products from qinghao<br/>3. Reaction of qinghaosu<br/> 3.1. Reduction of qinghaosu<br/> 3.2. Acidic degradation of qinghaosu<br/> 3.3. Miscellaneous chemical reaction<br/> 3.4. Biotransformation<br/>4. Chemical synthesis and biosynthesis<br/> 4.1. Partial synthesis and total synthesis<br/> 4.2. Biogenetic synthesis<br/>5. Derivatives and antimalarial activity <br/> 5.1. Modification on C-12 of qinghaosu<br/> 5.2. Water-soluble qinghaosu derivatives<br/> 5.3. Modification on C-11 or/and C-12<br/> 5.4. Modification on C- 4 or/and C-12<br/> 5.5. Modification on C-3 or/and C-13<br/> 5.6. Modification on C-13<br/> 5.7. Modification on C-11 and C-12<br/> 5.8. Steroidal qinghaosu derivatives<br/> 5.9. Dimers<br/> 5.10. 1,2,4 -Trioxanes and 1,2,4,5 - tetraoxanes<br/>6. Pharmacology and Chemical biology of qinghaosu and its derivatives<br/> 6.1 Bioactivities of qinghaosu derivatives and analogs<br/> 6.2 Early biologically morphologic observation of the antimalarial action of qinghaosu<br/> 6.3. The free radical reaction of qinghaosu and its derivatives with Fe(II)<br/> 6.4. Antimalarial activity and the free radical reaction of qinghaosu and its derivatives<br/> 6.5. Interaction of biomolecules with carbon-centered free radical<br/>7. Conclusion<br/>References<br/>Chapter 6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of Sarcophyton Genus<br/>Yulin Li, Lizeng Peng and Tao Zhang<br/>1. Introduction<br/>2. Cembrane-type constituents from Sarcophyton genus<br/> 2.1 Sarcophytols from Sarcophyton enus<br/> 2.2 The Other Cembrane-type Constituents from Sarcophyton Genus<br/>3. Physiological action of sarcophytol A and Sarcophytol B <br/>4. Total synthesis of the natural cembranoids <br/> 4.1 Total Synthesis of Sarcophytols<br/> 4.2 Total Synthesis of Cembrene A and C<br/> 4.3 Total Synthesis of Several Natural Epoxy Cembrenoids<br/> 4.4 Total Synthesis of Cembranolides<br/>5. Studies on novel macrocyclization methods of cembrane-type diterpenoid<br/> 5.1 A Stille Cyclization Approach to (ñ)-Isocembrene<br/>6. Acknowledgments<br/>7. References <br/>Chapter 7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba<br/>Kristan Stromgaard<br/>1. Introduction<br/> 1.1 Ginkgo biloba extract<br/> 1.2 Isolation and structure elucidation of ginkgolides<br/> 1.3 Biosynthesis of ginkgolides<br/> 1.4 Chemistry of ginkgolides<br/>2. Ginkgolides and the PAF Receptor<br/>3. Ginkgolides and Glycine Receptors<br/>4. Various Effects of Ginkgolides<br/>5. Conclusions and Outlook |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Chapter 8 Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents<br/>Lin Wang<br/>1. Introduction<br/>2. Anti-HIV-1 activity of Calophyllum coumarins<br/>2.1 Anti-HIV-1 activity of Calanolides<br/>2.2 Anti-HIV-1 activity of Inophyllums<br/>2.3 Anti-HIV-1 activity of Cordatolides<br/>3. Pharmacology of Calanolides<br/>3.1 Pharmacology of (+)-Calanolide A (I)<br/>3.2 Clinical trial of (+)-Calanolide A<br/>4. Preparation of Calophyllum coumarins<br/>4.1 Total synthesis of racemic Calophyllum coumarins<br/>4.2 Preparation of optically active Calophyllum coumarins<br/>5. Structure modification of Calanolides<br/>6. Conclusion<br/>Chapter 9 Recent Progress and Prospects on Plant-derived Anti-HIV Agents and Analogs<br/>Dong-lei Yu, K.-H. Lee<br/>1. Introduction<br/>2. Khellactone Coumarin Analogs as Anti-HIV Agents<br/>2.1 Suksdorfin as a new anti-HIV agent<br/>2.2 Pyrano-3?,4? Stereoselectivity and Modification<br/>2.3 Coumarin Skeleton Modification<br/>2.4 Structure-Activity Relationship Conclusions<br/>2.5 Mechanism of Action <br/>3. Biphenyl Derivatives as Anti-HIV Agents<br/>3.1 SAR analysis of naturally occurring dibenzocyclooctadiene lignans<br/>3.2 Structural Modifications<br/>3.3 SAR conclusions<br/>3.4 Mechanism of Action of Biphenyl Derivatives<br/>4. Triterpene betulinic acid derivatives as anti-HIV agents<br/>4.1 Betulinic acid derivatives as entry inhibitors <br/>4.2 Betulinic acid derivatives as maturation inhibitors<br/>4.3 Bifunctional betulinic acid derivatives with two novel mechanisms of action<br/>5. Conclusions<br/>6. Acknowledgements<br/>Chapter 10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and their structurally modified mimics<br/>Tai-Shan Hu, Yu-Lin Wu and Zhu-Jun Yao <br/>1. Introduction <br/>2. Total synthesis of mono-THF acetogenins <br/>3. Total synthesis of bis-THF acetogenins<br/>4. Total synthesis of THP-containing acetogenins<br/>5. Design and synthesis of mimics of acetogenins <br/>6. Summary |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Materia medica, Vegetable. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Pharmaceutical chemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Natural products. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Bioactive compounds. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Liang, Xiaotian. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fang, Wei-Shuo. |
| Relator term |
editor. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Books |
| Source of classification or shelving scheme |
Dewey Decimal Classification |