MARC details
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11681cam a22004457i 4500 |
| 001 - CONTROL NUMBER |
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18049189 |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20150311103356.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
140227s2014 enka b 001 0 eng d |
| 010 ## - LIBRARY OF CONGRESS CONTROL NUMBER |
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| LC control number |
2014934426 |
| 015 ## - NATIONAL BIBLIOGRAPHY NUMBER |
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| National bibliography number |
GBB423673 |
| Source |
bnb |
| 016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
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| Record control number |
016642421 |
| Source |
Uk |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780198705970 (hbk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
0198705972 (hbk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780199658572 (pbk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
0199658579 (pbk.) |
| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)ocn872702029 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
UKMGB |
| Language of cataloging |
eng |
| Transcribing agency |
UKMGB |
| Description conventions |
rda |
| Modifying agency |
OCLCO |
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YDXCP |
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CDX |
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LTSCA |
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HEBIS |
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DLC |
| 042 ## - AUTHENTICATION CODE |
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| Authentication code |
lccopycat |
| 050 00 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH506 |
| Item number |
.M6628 2014 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
572.8 |
| Edition number |
23 |
| Item number |
C.N.M |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Craig, Nancy Lynn, |
| Dates associated with a name |
1952- |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Molecular biology : |
| Remainder of title |
principles of genome function / |
| Statement of responsibility, etc |
Nancy L. Craig [and five others] ; with end of chapter questions by Deborah Zies and Claire Burns. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
Second edition. |
| 264 #1 - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc |
Oxford, United Kingdom ; |
| -- |
New York, NY, United States of America : |
| Name of publisher, distributor, etc |
Oxford University Press, |
| Date of publication, distribution, etc |
[2014] |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xxxi, 912 pages : |
| Other physical details |
illustrations (chiefly color) ; |
| Dimensions |
28 cm |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
unmediated |
| Media type code |
n |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Carrier type code |
nc |
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rdacarrier |
| 500 ## - GENERAL NOTE |
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| General note |
pharmacy bookfair2015 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Machine generated contents note: 1.Genomes and the 1low of biological information --<br/>Introduction --<br/>1.1.The roots of biology --<br/>1.2.The genome: a working blueprint for life --<br/>1.3.Bringing genes to life: gene expression --<br/>1.4.Regulating gene expression --<br/>1.5.Cellular infrastructure and gene expression --<br/>1.6.Expression of the genome --<br/>1.7.Evolution of the genome and the tree of life --<br/>2.Biological molecules --<br/>Introduction --<br/>2.1.Atoms, molecules, and chemical bonds --<br/>2.2.Life in aqueous solution --<br/>2.3.Non-covalent interactions --<br/>2.4.Nucleotides and nucleic acids --<br/>2.5.The structure of DNA --<br/>2.6.Chemical properties of RNA --<br/>2.7.RNA folding and structure --<br/>2.8.The RNA world and its role in the evolution of modern-day life --<br/>2.9.Fundamentals of protein structure --<br/>2.10.Protein folding --<br/>2.11.Protein folds --<br/>2.12.Protein-DNA interactions --<br/>2.13.Sugars and carbohydrates --<br/>2.14.Lipids --<br/>2.15.Chemical modification in biological regulation --<br/>Contents note continued: 3.The chemical basis of life --<br/>Introduction --<br/>3.1.Thermodynamic rules In biological systems --<br/>3.2.Binding equilibria and kinetics --<br/>3.3.Binding processes in biology --<br/>3.4.Enzyme catalysis --<br/>3.5.Enzyme kinetics --<br/>4.Chromosome structure and function --<br/>Introduction --<br/>4.1.Organization of chromosomes --<br/>4.2.The cell cycle and chromosome dynamics --<br/>4.3.Packaging chromosomal DNA --<br/>4.4.Variation in chromatin structure --<br/>4.5.Covalent modifications of histones --<br/>4.6.Nucleosome-remodeling complexes --<br/>4.7.DNA methylation --<br/>4.8.The separation of chromatin domains by boundary elements --<br/>4.9.Elements required for chromosome function --<br/>4.10.The centromere --<br/>4.11.The telomere --<br/>4.12.Chromosome architecture in the nucleus --<br/>5.The cell cycle --<br/>Introduction --<br/>5.1.Steps in the eukaryotic cell cycle --<br/>5.2.Cyclins and Cdks --<br/>5.3.Regulation of Cdk activity --<br/>5.4.Cell cycle regulation by Cdks --<br/>5.5.Regulation of proteolysis by Cdks --<br/>Contents note continued: 5.6.Checkpoints: Intrinsic pathways that can halt the cell cycle --<br/>5.7.Extrinsic regulators of cell cycle progression --<br/>5.8.The cell cycle and cancer --<br/>5.9.The bacterial cell cycle --<br/>6.DNA replication --<br/>Introduction --<br/>6.1.Overview of DNA replication --<br/>6.2.DNA polymerases: structure and function --<br/>6.3.DNA polymerases: fidelity and processivity --<br/>6.4.Specialized polymerases --<br/>6.5.DNA helicases: unwinding of the double helix --<br/>6.6.The sliding clamp and clamp loader --<br/>6.7.Origins and initiation of DNA replication --<br/>6.8.Leading and lagging strand synthesis --<br/>6.9.The replication fork --<br/>6.10.Termination of DNA replication --<br/>6.11.The end-replication problem and telomerase --<br/>6.12.Chromatin replication --<br/>6.13.Regulation of initiation of replication In E. coli --<br/>6.14.Regulation of replication initiation in eukaryotes --<br/>7.Chromosome segregation --<br/>Introduction --<br/>7.1.The stages of mitosis --<br/>7.2.Chromosome condensation and cohesion --<br/>Contents note continued: 7.3.The mitotic spindle --<br/>7.4.Prometaphase and metaphase --<br/>7.5.Anaphase: an irreversible step in chromosome segregation --<br/>7.6.The completion of mitosis and cytokinesis --<br/>7.7.Meiosis: generating haploid gametes from diploid calls --<br/>7.8.Chromosome segregation in bacteria --<br/>8.Transcription --<br/>Introduction --<br/>8.1.Overview of transcription --<br/>8.2.RNA polymerase core enzyme --<br/>8.3.Promoter recognition in bacteria and eukaryotes --<br/>8.4.Initiation of transcription and transition to an elongating complex --<br/>8.5.Transcription elongation --<br/>8.6.Transcription termination --<br/>9.Regulation of transcription --<br/>Introduction --<br/>9.1.Principles of transcription regulation --<br/>9.2.DNA-binding domains in proteins that regulate transcription --<br/>9.3.Mechanisms for regulating transcription initiation in bacteria --<br/>9.4.Competition between cl and Cro and control of the fate of bacteriophage lambda --<br/>9.5.Regulation of transcription termination in bacteria --<br/>Contents note continued: 9.6.Regulation of transcription initiation and elongation in eukaryotes --<br/>9.7.Combinatorial regulation of eukaryotic transcription --<br/>9.8.The role of signaling cascades in the regulation of transcription --<br/>9.9.Gene silencing --<br/>10.RNA processing --<br/>Introduction --<br/>10.1.Overview of RNA processing --<br/>10.2.tRNA and rRNA processing --<br/>10.3.tRNA and rRNA nucleotide modifications --<br/>10.4.mRNA capping and polyadenylation --<br/>10.5.RNA splicing --<br/>10.6.Eukaryotic mRNA splicing by the spliceosome --<br/>10.7.Exon definition and alternative splicing --<br/>10.8.RNA editing --<br/>10.9.Degradation of normal RNAs --<br/>10.10.Degradation of foreign and defective RNAs --<br/>10.11.RNA-binding domains in proteins --<br/>11.Translation --<br/>Introduction --<br/>11.1.Overview of translation --<br/>11.2.tRNA and the genetic code --<br/>11.3.Aminoacyl-tRNA synthetases --<br/>11.4.Structure of the ribosome --<br/>11.5.The translation cycle: the ribosome in action --<br/>Contents note continued: 11.6.Protein factors critical to the translation cycle --<br/>11.7.Translation initiation --<br/>shared features in bacteria and eukaryotes --<br/>11.8.Bacterial translation initiation --<br/>11.9.Eukaryotic translation initiation --<br/>11.10.Translation elongation: decoding, peptide bond formation, and translocation --<br/>11.11.Translation termination, recycling, and reinitiation --<br/>11.12.Ribosome rescue in bacteria and eukaryotes --<br/>11.13.Recoding: program med stop codon read-through and frameshifting --<br/>11.14.Antibiotics that target the ribosome --<br/>12.Regulation of translation --<br/>Introduction --<br/>12.1.Global regulation of initiation in bacteria and eukaryotes --<br/>12.2.Regulation of initiation by cis acting sequences in the 5' untranslated region in bacteria and eukaryotes --<br/>12.3.Regulation of translation through cis acting sequences in the 3' UTR in eukaryotes --<br/>12.4.Viral corruption of the translational machinery --<br/>13.Regulatory RNAs --<br/>Introduction --<br/>Contents note continued: 13.1.Overview of regulatory RNAs --<br/>13.2.Bacterial base-pairing sRNAs --<br/>13.3.Eukaryotic sRNAs: miRNAs, siRNAs, and rasiRNAs --<br/>13.4.Processing of eukaryotic sRNAs --<br/>13.5.Loading of Argonaute family proteins with eukaryotic sRNAs --<br/>13.6.Gene silencing by small eukaryotic RNAs --<br/>13.7.Viral defense role of bacterial, archaeal, and eukaryotic sRNAs --<br/>13.8.RNA-mediated regulation in cis --<br/>13.9.Protein-binding regulatory RNAs --<br/>13.10.Long intergenic non-coding RNAs --<br/>14.Protein modification and targeting --<br/>Introduction --<br/>14.1.Chaperone-assisted protein folding --<br/>14.2.Targeting of proteins throughout the cell --<br/>14.3.Post-translational cleavage of the polypeptide chain --<br/>14.4.Lipid modification of proteins --<br/>14.5.Glycosylation of proteins --<br/>14.6.Protein phosphorylation, acetylation, and methylation --<br/>14.7.Protein modification by nucleotides --<br/>14.8.Direct chemical modification of proteins --<br/>14.9.Ubiquitination and sumoylation of proteins --<br/>Contents note continued: 14.10.Protein degradation --<br/>15.Cellular responses to DNA damage --<br/>Introduction --<br/>15.1.Types of DNA damage --<br/>15.2.Post-replication mismatch repair --<br/>15.3.Repair of DNA damage by direct reversal --<br/>15.4.Repair of DNA damage by base excision repair --<br/>15.5.Nucleotide excision repair of bulky lesions --<br/>15.6.Translesion DNA synthesis --<br/>15.7.The DNA damage response --<br/>15.8.The DNA damage response in bacteria --<br/>15.9.The DNA damage response in eukaryotes --<br/>15.10.DNA damage and cell death in mammalian cells --<br/>16.Repair of DNA double-strand breaks and homologous recombination --<br/>Introduction --<br/>16.1.An overview of DNA double-strand break repair and homologous recombination --<br/>16.2.Double-strand break repair by NHEJ --<br/>16.3.Homology-directed repair of double-strand breaks --<br/>16.4.Generation of single-stranded DNA by helicases and nucleases --<br/>16.5.The mechanism of DNA strand pairing and exchange --<br/>16.6.Gene conversion through homology-directed repair --<br/>Contents note continued: 16.7.Repair of damaged replication forks by homology-directed repair --<br/>16.8.Homologous recombination --<br/>16.9.Chromosome rearrangements during aberrant repair and recombination --<br/>17.Mobile DNA --<br/>Introduction --<br/>17.1.Transposable elements: overview --<br/>17.2.An overview of DNA-only transposons --<br/>17.3.DNA-only cut-and-paste transposition --<br/>17.4.DNA-only nick-and-paste transposition --<br/>17.5.DNA cut-and-paste transposition in adaptive immunity --<br/>17.6.Retrotransposons --<br/>17.7.LTR retrotransposons --<br/>17.8.Non-LTR retrotransposons --<br/>17.9.Control of transposition --<br/>17.10.CSSR: overview --<br/>17.11.CSSR systems that control gene expression --<br/>17.12.CSSR conversion of DNA dimers to monomers --<br/>17.13.Bacteriophage lambda Integration and excision --<br/>18.Genomics and genetic variation --<br/>Introduction --<br/>18.1.Genome sequences and sequencing projects --<br/>18.2.Finding functions in a genome --<br/>18.3.Functional genomics --<br/>18.4.The ENCODE project --<br/>Contents note continued: 18.5.The evolving genome: evolutionary forces --<br/>18.6.The evolving genome: mechanisms of variation --<br/>18.7.Gene duplication and divergence of gene function --<br/>18.8.Changes In chromosome structure and copy number variation --<br/>18.9.Epigenetics and imprinting --<br/>18.10.Human genetic diseases: finding disease loci --<br/>18.11.Human genetics: impacts and implications --<br/>19.Tools and techniques in molecular biology --<br/>Introduction --<br/>19.1.Model organisms --<br/>19.2.Cultured cells and viruses --<br/>19.3.Amplification of DNA and RNA sequences --<br/>19.4.DNA cloning --<br/>19.5.Genome manipulation --<br/>19.6.Detection of biological molecules --<br/>19.7.Separation and isolation of biological molecules --<br/>19.8.Identifying the composition of biological molecules --<br/>19.9.Detection of specific DNA sequences --<br/>19.10.Detection of specific RNA molecules --<br/>19.11.Detection of specific proteins --<br/>19.12.Detection of interactions between molecules --<br/>19.13.Imaging cells and molecules --<br/>Contents note continued: 19.14.Molecular structure determination --<br/>19.15.Obtaining and analyzing a complete genome sequence. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Genomes. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molekulargenetik |
| Source of heading or term |
gnd |
| 906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
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| a |
7 |
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cbc |
| c |
copycat |
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2 |
| e |
ncip |
| f |
20 |
| g |
y-gencatlg |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Books |