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Using mass spectrometry for drug metabolism studies / edited by Walter A. Korfmacher.

Contributor(s): Material type: TextTextPublisher: Boca Raton, FL : CRC Press, [2005]Copyright date: ©2005Description: xii, 370 pages : illustartions ; 24 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 0849319633 (alk. paper)
Subject(s): DDC classification:
  • 615.7 22 U
LOC classification:
  • RM301 .U85 2005
NLM classification:
  • QV 38
Online resources:
Contents:
Bioanalytical Assays in a Drug Discovery Environment -- Walter A. Korfmacher Drug Metabolism In-vitro and In-vivo Results: How do these Data Support Drug Discovery? -- Thomas N. Thompson High Throughput Strategies forIn Vitro ADME Assays: How Fast Can We Go? --Dan Kassel, Matrix Effects: Causes and Solutions -- Hong Mei Direct Plasma Analysis Systems -- Yunsheng Hsieh Acyl Glucuronides-Assays and Issues -- Sam Wainhaus Utilizing Higher Mass Resolution in Quantitative Assays -- Xiaoying Xu Special Requirements for Metabolite Characterization -- Kathleen Cox APPI: A New Ionization Source for LC-MS/MS Assays -- Yunsheng Hsieh Q Trap MS: a New Tool for Metabolite Identification -- Gerard Hopfgartner and Manfred Zell MS Imaging: New Technology Provides New Opportunities -- Michelle L. Reyzer and Richard M. Caprioli Understanding the Role and Potential of Infusion Nanoelectrospray Ionization for Pharmaceutical Bioanalysis -- Bradley L. Ackermann and Jean-Marie Dethy
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Includes bibliographical references and index.

Bioanalytical Assays in a Drug Discovery Environment -- Walter A. Korfmacher Drug Metabolism In-vitro and In-vivo Results: How do these Data Support Drug Discovery? -- Thomas N. Thompson High Throughput Strategies forIn Vitro ADME Assays: How Fast Can We Go? --Dan Kassel, Matrix Effects: Causes and Solutions -- Hong Mei Direct Plasma Analysis Systems -- Yunsheng Hsieh Acyl Glucuronides-Assays and Issues -- Sam Wainhaus Utilizing Higher Mass Resolution in Quantitative Assays -- Xiaoying Xu Special Requirements for Metabolite Characterization -- Kathleen Cox APPI: A New Ionization Source for LC-MS/MS Assays -- Yunsheng Hsieh Q Trap MS: a New Tool for Metabolite Identification -- Gerard Hopfgartner and Manfred Zell MS Imaging: New Technology Provides New Opportunities -- Michelle L. Reyzer and Richard M. Caprioli Understanding the Role and Potential of Infusion Nanoelectrospray Ionization for Pharmaceutical Bioanalysis -- Bradley L. Ackermann and Jean-Marie Dethy

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