Handbook of pharmacogenomics and stratified medicines / edited by Sandosh Padmanabhan, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.

Contributor(s):

Padmanabhan, Sandosh [editor of compilation.]

Material type: Text

text

Media type:

unmediated

Carrier type:

volume

ISBN:

9780123868824
0123868823

Subject(s):

DDC classification:

615.7 23 H

LOC classification:

RM301.3.G45 H36 2014

NLM classification:

QV 38.5

Online resources:

Abstract

Contents:

Machine generated contents note: pt. I Introduction -- 1.Pharmacogenomics and Stratified Medicine / Sandosh Padmanabhan -- 1.1.Overview -- 1.2.The Genetic Basis of Drug Response and Adverse Effects -- 1.3.Single-Gene Studies -- 1.4.Genome-Wide Association Studies in Pharmacogenomics -- 1.5.The Road to Personalization and Stratification -- 1.6.Pharmacogenetic Biomarkers and Companion Diagnostics -- 1.7.Economic Challenges -- 1.8.Conclusions -- References -- pt. II Basic Genetics -- 2.Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws / Guan Wang -- 2.1.Overview of the Cell: Anatomy, Components, and Function -- 2.2.Cell Reproduction: Cell Cycle and Mitosis -- 2.3.Meiosis -- 2.4.Mendelian Laws -- 2.5.Public Databases for Biomedical Research in Humans -- 2.6.Conclusion -- Glossary -- Acknowledgments -- References -- 3.The Human Genome, Gene Regulation, and Genomic Variation / Edward S. Tobias -- 3.1.Overview: Structure of the Human Genome -- 3.2.Gene Structures -- Contents note continued: 3.3.Gene Expression -- 3.4.Gene Regulation -- 3.5.Genomic Variation -- 3.6.Conclusion -- References -- 4.Epigenetics / Peter D. Adams -- 4.1.Overview -- 4.2.DNA Methylation -- 4.3.Histones and Variants -- 4.4.Epigenetic Disorders and Therapies -- 4.5.Conclusion -- References -- pt. III Experimental and Discovery Platforms -- 5.Animal Models in Pharmacogenomics / Delyth Graham -- 5.1.Overview -- 5.2.Rodent Models -- 5.3.Nonrodent Models of Human Disease -- 5.4.Genetic/Genomic Resources -- 5.5.Ethical Issues of Animal Experimentation -- 5.6.Caution and Limitations -- 5.7.Applications of in vivo Models in Pharmacogenomic Research -- 5.8.Rodent Models in Pharmacogenomics -- 5.9.Conclusion -- References -- 6.Human Lymphoblastoid Cell Lines in Pharmacogenomics / Jae-Pil Jeon -- 6.1.Overview -- 6.2.Generation of LCLs -- 6.3.Biological Characteristics of LCLs -- 6.4.Potentials and Limitations of LCL Applications -- 6.5.Future Perspectives -- Acknowledgments -- Contents note continued: References -- 7.Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches in Pharmacogenomic Studies / Federico Innocenti -- 7.1.Overview -- 7.2.Liver eQTL Studies -- 7.3.Future Directions -- 7.4.Conclusion -- Acknowledgments -- Glossary -- Acronyms and Abbreviations -- References -- 8.Next-Generation Sequencing / Pawel Herzyk -- 8.1.Overview -- 8.2.First-Generation Sequencing: Chain Termination Method -- 8.3.The Concept of Next-Generation Sequencing -- 8.4.Application-Independent Data Analysis -- 8.5.Genomic Applications -- 8.6.Transcriptomic Applications -- 8.7.Epigenomic Applications -- 8.8.Metagenomic Applications...

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Books	Main library A11	Pharmacy ( Clinical Pharmacy )	615.7 H (Browse shelf(Opens below))	Available		00012602

pharmacy bookfair2016

Includes bibliographical references and index.

Machine generated contents note: pt. I Introduction --
1.Pharmacogenomics and Stratified Medicine / Sandosh Padmanabhan --
1.1.Overview --
1.2.The Genetic Basis of Drug Response and Adverse Effects --
1.3.Single-Gene Studies --
1.4.Genome-Wide Association Studies in Pharmacogenomics --
1.5.The Road to Personalization and Stratification --
1.6.Pharmacogenetic Biomarkers and Companion Diagnostics --
1.7.Economic Challenges --
1.8.Conclusions --
References --
pt. II Basic Genetics --
2.Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws / Guan Wang --
2.1.Overview of the Cell: Anatomy, Components, and Function --
2.2.Cell Reproduction: Cell Cycle and Mitosis --
2.3.Meiosis --
2.4.Mendelian Laws --
2.5.Public Databases for Biomedical Research in Humans --
2.6.Conclusion --
Glossary --
Acknowledgments --
References --
3.The Human Genome, Gene Regulation, and Genomic Variation / Edward S. Tobias --
3.1.Overview: Structure of the Human Genome --
3.2.Gene Structures --
Contents note continued: 3.3.Gene Expression --
3.4.Gene Regulation --
3.5.Genomic Variation --
3.6.Conclusion --
References --
4.Epigenetics / Peter D. Adams --
4.1.Overview --
4.2.DNA Methylation --
4.3.Histones and Variants --
4.4.Epigenetic Disorders and Therapies --
4.5.Conclusion --
References --
pt. III Experimental and Discovery Platforms --
5.Animal Models in Pharmacogenomics / Delyth Graham --
5.1.Overview --
5.2.Rodent Models --
5.3.Nonrodent Models of Human Disease --
5.4.Genetic/Genomic Resources --
5.5.Ethical Issues of Animal Experimentation --
5.6.Caution and Limitations --
5.7.Applications of in vivo Models in Pharmacogenomic Research --
5.8.Rodent Models in Pharmacogenomics --
5.9.Conclusion --
References --
6.Human Lymphoblastoid Cell Lines in Pharmacogenomics / Jae-Pil Jeon --
6.1.Overview --
6.2.Generation of LCLs --
6.3.Biological Characteristics of LCLs --
6.4.Potentials and Limitations of LCL Applications --
6.5.Future Perspectives --
Acknowledgments --
Contents note continued: References --
7.Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches in Pharmacogenomic Studies / Federico Innocenti --
7.1.Overview --
7.2.Liver eQTL Studies --
7.3.Future Directions --
7.4.Conclusion --
Acknowledgments --
Glossary --
Acronyms and Abbreviations --
References --
8.Next-Generation Sequencing / Pawel Herzyk --
8.1.Overview --
8.2.First-Generation Sequencing: Chain Termination Method --
8.3.The Concept of Next-Generation Sequencing --
8.4.Application-Independent Data Analysis --
8.5.Genomic Applications --
8.6.Transcriptomic Applications --
8.7.Epigenomic Applications --
8.8.Metagenomic Applications...

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