Integrated drug discovery technologies / edited by Houng-Yau Mei, Anthony W. Czarnik.

Includes bibliographical references and index.

. The Motivation: A Top-Down View / Wendell Wierenga -- 2. Target Identification and Validation: Coupling Genotype to Phenotype / Gary McMaster -- 3. Functional Genomics / David O'Hagan -- 4. Integrated Proteomics Technologies / Joseph A. Loo, James A. Blackledge and Ping Du / [and others] -- 5. Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications / Tony J. Beugelsdijk -- 6. SNP Scoring for Drug Discovery Applications / John P. Nolan, P. Scott White and Hong Cai -- 7. Protein Display Chips / Tina S. Morris -- 8. Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets / Christian Rohlff -- 9. High-Throughput Screening as a Discovery Resource / John P. Devlin -- 10. Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS[superscript +] plus): Multiple Read-Out Options for Miniaturized Screening / Cornelia Rufenach, Andreas Scheel and Sylvia Sterrer / [and others] -- 11. Homogeneous Time-Resolved Fluorescence / Loraine V. Upham, Jocelyn W. Burke and Betty Howard / [and others] -- 12. ADME-Tox Screening in Drug Discovery / Albert P. Li -- 13. Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells / Kenneth A. Giuliano, Ravi Kapur and Keith R. Olson / [and others] -- 14. Miniaturization Technologies for High-Throughput Biology / Walter D. Niles and Peter J. Coassin -- 15. Data Management for High-Throughput Screening / Lee Amon -- 16. Combinatorial Chemistry: The History and the Basics / Michal Lebl -- 17. New Synthetic Methodologies / Tasir S. Haque, Andrew P. Combs and Lorin A. Thompson -- 18. Supports for Solid-Phase Synthesis / Christophe Fromont, Vincent Pomel and Mark Bradley -- 19. The NMR "Toolkit" for Compound Characterization / Paul A. Keifer -- 20. Materials Management / David A. Kniaz.