Handbook of drug metabolism / edited by Thomas F. Woolf.

Includes bibliographical references and index.

Part 1 Fundamental Aspects of Drug Metabolism 1. Pharmacokinetics of Drug Metabolites / Philip C. Smith -- 2 Oxidative Metabolic Bioactivation of Xenobiotics /Stéphane Mabic, Kay Castagnoli, and Neal Castagnoli, Jr. -- 3. Morphofunctional Aspects of the Hepatic Architecture: Functional and Subcellular Corelates / Felix A. de la lglesia, Donald G. Robertson, and Jeffrey R. Haskins The Cytochrome P450 Oxidative System / Paul R. Ortiz de Montellano -- 5. Transformation Enzymes: Oxidative: Non-P450 / Allen E. Rettie and Michael B. Fisher Transformation Reactions: Glucuronidation Brian Burchell Part 2 Factors Affecting Drug Metabolism Pharmacogenetics Ann K. Daly -- Inhibition of Drug Metabolizing Enzymes: Molecular und Biochermical F. Peter Guengerich 2. Metabolic Drug Interactions Wayne D. Hooper 10. Induction of Human Drug-Metabolizing Enzymes: Mechanisms and Implications Martin J. J. Ronis and Magnus Ingelman-Sundberg 11 Sites of Metabolism: Lung Garold S. Yost Part 3 Technologies 12 Applications of Heterologous Expressed and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective A. David Rodrigues 13 In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool in Drug Development Thomas Friedberg, C. J. Henderson, M. P. Pritchard, and C. R. Wolf 14 In Vitro Metabolism Subcellular Eractions Sean Ekins, Jukka Mäenpää, and Steven A. Wrighton 15 In Vitro Metabolism Hepatocytes Michael W. Sinz 16 The Isalated PerfusedLiver as a Tool in Drug Mctabolism Studies -- Michael W. SinZ 16 The Isolated Perfused Liver as a Tool in Drug Metabolism Studies Marián Kukan 17 Metabolic Models of Cytotoxicity Munir Pirmohamed and B. Kevin Park 18. In Vitro Metabolism: FMO and Related Oxygenations John R. Cashman 19 Applications of Caco-2 Cells in Drug Discovery and Development Shiyin Yee and Wesley W. Day 20. The Role of Nuclear Magnetic Resonance Spectroscopy in Drug Metabolism 1. D. Wilson, J. K. Nicholson, and J. C. Lindon -- Part 4 Metabolism in Drug Discovery and Development 21. Preclinical Drug Metabolism Studies and Strate gies Philip B. Inskeep and Wesley W. Day 22 Clinical Drug Metabolism Studies William F. Pool.