Handbook of Drug Metabolism / edited by Paul G. Pearson, Larry C. Wienkers

Contributor(s):

Material type: Text

TextSeries: Drugs and the pharmaceutical sciencesPublisher: [New York] : CRC Press, 2019Edition: Third editionDescription: 735 pages : illustrations ; 24 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

ISBN:

9780429190315
042919031X

Subject(s):

Drugs -- Metabolism -- Handbooks, manuals, etc

DDC classification:

615.7 23 H

LOC classification:

RM301.55

Online resources:

CRCnetBASE. Restricted to UC campuses

Contents:

Section I: Fundamental Aspects of Drug Metabolism -- Chapter 1: The Evolution of Drug Metabolism Research -- Chapter 2: Pharmacokinetics of Drug Metabolites -- Chapter 3: The Cytochrome P450 Oxidative System -- Chapter 4: Aldehyde Oxidases an Emerging Group of Enzymes Involved in Xenobiotic Metabolism: Evolution, Structure, and Function -- Chapter 5: UDP-Glucuronosyltransferases -- Section II: Factors Which Affect Drug Metabolism -- Chapter 6: Non-CYP Drug Metabolizing Enzymes and Their Reactions -- Chapter 7: The Genetic Basis of Variation in Drug Metabolism and Toxicity -- Chapter 8: Inhibition of Drug Metabolizing Enzymes -- Chapter 9: Quantitative Approaches to Human Clearance Projection in Drug Research and Development -- Chapter 10: Sites of Extra Hepatic Metabolism, Part I: The Airways and Lung -- Chapter 11: Sites of Extra Hepatic Metabolism, Part II: Gut -- Chapter 12: Sites of Extra Hepatic Metabolism, Part III: Kidney -- Section III: Technologies to Study Drug Metabolism -- Chapter 13: Mass Spectrometry in Drug Metabolism Research: Principles and Common Practice -- Chapter 14: The Role of NMR as a Qualitative and Quantitative Analytical Technique in Biotransformation Studies -- Chapter 15: In Vitro Metabolism: Subcellular Fractions -- Chapter 16: Drug Interaction Studies in the Drug Development Process: Studies In Vitro -- Chapter 17: Enzyme Induction Studies in Drug Discovery and Development -- Chapter 18: Transporters in Drug Discovery and Development -- Chapter 19: Experimental Characterization of Cytochrome P450 Mechanism-Based Inhibition -- Section IV: Applications of Metabolism Studies in Drug Discovery and Development -- Chapter 20: Clinical Drug Metabolism -- Chapter 21: Managing Metabolic Activation Issues in Drug Discovery -- Chapter 22: Kinetic Differences between Generated and Preformed Metabolites: A Dilemma in Risk Assessment -- Chapter 23: Numerical Approaches to Drug Metabolism Kinetics and Pharmacokinetics -- Chapter 24: Active Metabolites in Drug Development -- Chapter 25: ADME of Antibody Drug Conjugates -- Chapter 26: Managing Reactive Metabolites in Drug Discovery and Development -- Chapter 27: Applications of 14C Accelerator Mass Spectrometry in Drug Development.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Books	Main library A11	Pharmacy ( Pharmacology )	615.7 H (Browse shelf(Opens below))	Available		00015292

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Includes bibliographical references and index.

Section I: Fundamental Aspects of Drug Metabolism --
Chapter 1: The Evolution of Drug Metabolism Research --
Chapter 2: Pharmacokinetics of Drug Metabolites --
Chapter 3: The Cytochrome P450 Oxidative System --
Chapter 4: Aldehyde Oxidases an Emerging Group of Enzymes Involved in Xenobiotic Metabolism: Evolution, Structure, and Function --
Chapter 5: UDP-Glucuronosyltransferases --
Section II: Factors Which Affect Drug Metabolism --
Chapter 6: Non-CYP Drug Metabolizing Enzymes and Their Reactions --
Chapter 7: The Genetic Basis of Variation in Drug Metabolism and Toxicity --
Chapter 8: Inhibition of Drug Metabolizing Enzymes --
Chapter 9: Quantitative Approaches to Human Clearance Projection in Drug Research and Development --
Chapter 10: Sites of Extra Hepatic Metabolism, Part I: The Airways and Lung --
Chapter 11: Sites of Extra Hepatic Metabolism, Part II: Gut --
Chapter 12: Sites of Extra Hepatic Metabolism, Part III: Kidney --
Section III: Technologies to Study Drug Metabolism --
Chapter 13: Mass Spectrometry in Drug Metabolism Research: Principles and Common Practice --
Chapter 14: The Role of NMR as a Qualitative and Quantitative Analytical Technique in Biotransformation Studies --
Chapter 15: In Vitro Metabolism: Subcellular Fractions --
Chapter 16: Drug Interaction Studies in the Drug Development Process: Studies In Vitro --
Chapter 17: Enzyme Induction Studies in Drug Discovery and Development --
Chapter 18: Transporters in Drug Discovery and Development --
Chapter 19: Experimental Characterization of Cytochrome P450 Mechanism-Based Inhibition --
Section IV: Applications of Metabolism Studies in Drug Discovery and Development --
Chapter 20: Clinical Drug Metabolism --
Chapter 21: Managing Metabolic Activation Issues in Drug Discovery --
Chapter 22: Kinetic Differences between Generated and Preformed Metabolites: A Dilemma in Risk Assessment --
Chapter 23: Numerical Approaches to Drug Metabolism Kinetics and Pharmacokinetics --
Chapter 24: Active Metabolites in Drug Development --
Chapter 25: ADME of Antibody Drug Conjugates --
Chapter 26: Managing Reactive Metabolites in Drug Discovery and Development --
Chapter 27: Applications of 14C Accelerator Mass Spectrometry in Drug Development.