Pharmaceutical chemistry : therapeutic aspects of biomacromolecules / Christine M. Bladon.

Title page verso: First Printing 2002

Includes bibliographical references and index.

Introduction -- Overview -- Endocrine disorders -- Severe combined immunodeficiency disorders -- Biomacromolecules in the Treatment of Human Disease -- Endogenous Peptides and Proteins -- Overview -- Isolation from Natural Tissues and Fluids II -- Synthesis and Semi-Synthesis -- Peptide synthesis -- Gene Cloning -- Growth hormone -- Transgenic Procedures -- Examples of Direct Replacement Strategy -- Insulin -- The fibrin and fibrinolytic cascades -- Modification of Endogenous Peptides and Protcins -- Overview -- Peptide Mimetics -- Mimetics based on luteinizing hormone-releasing hormone -- Mimetics based on somatostatin -- Chemical Modification of Proteins -- Immunoassays --Modification with synthetic polymers -- Modification of enzyme active sites -- Protein Engineering -- Site-directed mutagenesis -- Chimeric toxins -- Chimeric and humanized antibodies -- The single-chain Fv -- Phage display -- The Immune System Overview -- The Antibody-Mediated Response -- Polyclonal antibodies -- Monoclonal antibodies -- Vaccines -- Hepatitis B vaccine -- Approaches to an HIV vaccine -- The Cell-Mediated Immune Response -- Immunoenhancement II -- Immunosuppression -- Cancer Immunotherapy -- Antibody-mediated immunotherapy -- T-cell-mediated immunotherapy -- Oligonucleotides -- Overview -- Gene Therapy -- Introduction -- Ex vio gene delivery -- Clinical applications -- Antisense Therapy -- Introduction -- Development of an antisense oligonucieotide -- Clinical studies IST -- Oligosaccharides -- Overview -- Oligosaccharide Synthesis -- Heparin -- Glycoproteins -- Blood group oligosaccharides -- Polysaccharide Bacterial Vaccines -- Approaches to Carbohydrate-Based Cancer Vaccines -- Appendix -- A.1 Amino Acids and Peprides A.LI Abbeeviations and structural representations -- Secondary structures -- A.2 Oligonocleotides. DNA and RNA -- Carbohydrates -- index.