Bioadhesive drug delivery systems : fundamentals, novel approaches, and development / edited by Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr

Includes bibliographical references and index

I.Fundamentals of bioadhesion -- Definitions, mechanisms, and theories of bioadhesion -- The role of water movement and polymer hydration in mucoadhesion -- A rheological approach to explain the mucoadhesive behavior of polymer hydrogels -- Functional histology of epithelia relevant for drug delivery: respiratory tract, digestive tract, eye, skin, and vagina -- Biochemical and functional aspects of mucus and mucin-type glycoproteins -- II.Methods of evaluating bioadhesive interactions -- Adaptation of a microbalance to measure bioadhesive properties of microspheres -- Novel magnetic technique to measure bioadhesion -- Principles of skin adhesion and methods for measuring adhesion of transdermal systems -- Force microscopy of cells to measure bioadhesion -- Direct measurement of molecular-level forces and adhesion in biological systems -- A centrifugation method for measurement of two-dimensional binding characteristics of receptor-ligand interaction -- III.Novel concepts and strategies for bioadhesive drug delivery systems -- Multifunctional polymers for the peroral delivery of peptide drugs -- Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia -- Plant lectins for oral drug delivery to different parts of the gastrointestinal tract -- Bacterial invasion factors and lectins as second-generation bioadhesives -- Novel PEG-containing acrylate copolymers with improved mucoadhesive properties --Bioadhesive, bioerodible polymers for increased intestinal update -- IV.Development issues of bioadhesive drug delivery systems: products and clinical trials -- Novel formulation approaches to oral mucoadhesive drug delivery systems -- Bioadhesive formulations for nasal peptide delivery -- Development of bioadhesive buccal patches -- Vaginal delivery of calcitonin by hyaluronic acid formulations -- Ocular bioadhesive drug delivery systems -- bioadhesive preparations as topical dosage forms