Analytical study of some drugs containing Carbonyl group / Mona Nabil Mohamed Hassan, (B. Pharm. Sci., Future University in Egypt, 2013, Teaching Assistant in Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences &Pharmaceutical Industries, Future University in Egypt ), supervision of Prof. Dr. Samah Sayed Abbas, (Professor and Head of Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University), Prof. Dr. Amr Mohamed Badawey, (Professor of Analytical Chemistry, Faculty of Pharmacy, Cairo University and Future University in Egypt), Assoc. Professor Ali Mohamed Yehia, (Associate Professor of Analytical Chemistry, Faculty of Pharmacy, Cairo University and University of Hertfordshire Hosted by Global Academic Foundation).

supervision of Prof. Dr. Samah Sayed Abbas, (Professor and Head of Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University), Prof. Dr. Amr Mohamed Badawey, (Professor of Analytical Chemistry, Faculty of Pharmacy, Cairo University and Future University in Egypt), Assoc. Professor Ali Mohamed Yehia, (Associate Professor of Analytical Chemistry, Faculty of Pharmacy, Cairo University and University of Hertfordshire Hosted by Global Academic Foundation).

Thesis (M.Sc.)-Cairo university, Faculty of pharmacy, Department of Analytical Chemistry, 2021.

Includes bibliographical references.

Renal allograft survival requires multiple immunosuppressive drugs. This strategy
may lead to gastric complications that necessitate gastro-protective medications,
notably, proton pump inhibitors (PPI). This study aimed to compare the influence
of pantoprazole and esomeprazole on serum cyclosporine trough levels (C0) in
renal transplant recipients (RTR). A prospective, parallel, open-label trial was
conducted on 47 adult RTR receiving cyclosporine doses adjusted to attain trough
concentrations of 100 to 150 μg/L, mycophenolate mofetil (MMF) 750 mg
q12 hour and prednisolone at 5 mg daily at Nasser Institute, Cairo, Egypt from
January to September 2016. Patients were randomized into the esomeprazole
group (25) or pantoprazole group (22) receiving the same dose (40 mg once daily).
The study outcomes included clinical signs of rejection and renal function
decline, assessed by elevations in serum creatinine, caused by cyclosporine level
variations in either of the two study groups. Renal function, C0 and CBC measurements were measured at baseline and monthly for 6 months. The mean C0
values were higher in the pantoprazole group than in the esomeprazole group in
the sixth month only (P = .007). Serum creatinine level was lower in the sixth
month than at baseline in the esomeprazole group (P = .004). There were no
signs of rejection biochemical or clinical in any of the study groups. In conclusion,
PPIs should be used with caution and doses should be titrated to reach the C0 targets in RTR, which is of more importance in pantoprazole than esomeprazole to
avoid C0 level elevation or decline affecting the allograft function

Text in English, abstracts in English and Arabic.