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An introduction to medicinal chemistry / Graham L. Patrick.

By: Material type: TextTextPublisher: Oxford ; New York : Oxford University Press, 2001Edition: Second editionDescription: xxiii, 622 pages : illustrations ; 25 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 0198505337 (pbk.)
  • 9780198505334
  • 0195668863
  • 9780195668865
Subject(s): DDC classification:
  • 615.19 21 P.G.I.
Online resources:
Contents:
Drugs and drug targets : an overview. Drug targets. Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Pharmacodynamics and pharmacokinetics. Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery, design, and development. Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Tools of the trade. Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Selected topics in medicinal chemistry. Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opiod analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions.
Summary: This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug
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Holdings
Item type Current library Collection Call number Status Date due Barcode
Books Books Main library A10 Pharmacy ( Pharmaceutical chemistry ) 615.19 P.G.I. (Browse shelf(Opens below)) Available 00000655
Books Books Main library A10 Pharmacy ( Pharmaceutical chemistry ) 615.19 P.G.I. (Browse shelf(Opens below)) Available 00000663

Includes bibliographical references (p. [598]) and index.

Drugs and drug targets : an overview. Drug targets. Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Pharmacodynamics and pharmacokinetics. Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery, design, and development. Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Tools of the trade. Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Selected topics in medicinal chemistry. Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opiod analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions.

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug

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