The organic chemistry of drug design and drug action / Richard B. Silverman.

Includes bibliographical references and index.

Front Cover -- Dedication -- The Organic Chemistry of Drug Design and Drug Action -- Copyright Page -- Table of Contents -- Preface to the First Edition -- Preface to the Second Edition -- Chapter 1. Introduction -- 1.1 Medicinal Chemistry Folklore -- 1.2 Discovery of New Drugs -- 1.3 General References -- 1.4 References -- Chapter 2. Drug Discovery, Design, and Development -- 2.1 Drug Discovery -- 2.2 Lead Modification: Drug Design and Development -- 2.3 General References -- 2.4 Problems -- 2.5 References -- Chapter 3. Receptors -- 3.1 Introduction -- 3.2 Drug-Receptor Interactions -- 3.3 General References -- 3.4 Problems 3.5 References -- Chapter 4. Enzymes -- 4.1 Enzymes as Catalysts -- 4.2 Mechanisms of Enzyme Catalysis -- 4.3 Coenzyme Catalysis -- 4.4 Enzyme Therapy -- 4.5 General References -- 4.6 Problems -- 4.7 References -- Chapter 5. Enzyme Inhibition and Inactivation -- 5.1 Why Inhibit an Enzyme? -- 5.2 Drug Resistance -- 5.3 Drug Synergism (Drug Combination) -- 5.4 Reversible Enzyme Inhibitors -- 5.5 Irreversible Enzyme Inhibitors -- 5.6 General References -- 5.7 Problems -- 5.8 References -- Chapter 6. DNA-Interactive Agents -- 6.1 Introduction -- 6.2 DNA Structure and Properties -- 6.3 Classes of Drugs That Interact with DNA 6.4 Epilogue to Receptor-Interactive Agents6.5 General References -- 6.6 Problems -- 6.7 References -- Chapter 7. Drug Metabolism -- 7.1 Introduction -- 7.2 Synthesis of Radioactive Compounds -- 7.3 Analytical Methods in Drug Metabolism -- 7.4 Pathways for Drug Deactivation and Elimination -- 7.5 General References -- 7.6 Problems -- 7.7 References -- Chapter 8. Prodrugs and Drug Delivery Systems -- 8.1 Enzyme Activation of Drugs -- 8.2 Mechanisms of Drug Activation -- 8.3 General References -- 8.4 Problems -- 8.5 References -- Appendix: Answers to Chapter Problems -- Index