Chemical biology : learning through case studies / edited by Herbert Waldmann and Petra Janning.

Contributor(s):

Material type: Text

TextPublication details: Weinheim : Wiley-VCH, c2009.Description: xxxiii, 271 p. : ill. (some col.) ; 25 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

ISBN:

9783527323302 (pbk.)
3527323309 (pbk.)

Subject(s):

DDC classification:

21 547 C

LOC classification:

QD415 .C456 2009

Contents:

Yeast-based chemical genomic approaches / Katja Hubel -- Microarray-based strategies to identify unknown protein / Sabine Borgmann and Christof M. Niemeyer -- Compound collection synthesis for chemical biology / Kamal Kumar -- Target identification and validation of a WNT/P-catenin pathway modulator / Petra Janning -- Activity-based protein profiling of cys proteases / Renier van der Hoorn -- The use of photoaffinity labeling for the identification of the binding site of the antibiotic linezolid / Rolf Breinbauer and Matthias Mentel -- Surgical strikes : uses of analog sensitive technologies to target kinases of interest / Matthias Rabiller and Daniel Rauh -- Modulation of protein-protein interactions by small molecules / Stefanie Bovens and Christian Ottmann -- Targeted protein degradation in live cells / Markus Kaiser -- Trapoxin B : from total synthesis to epigenetics / Bruno Bulic -- Native chemical ligation : a tool for chemical protein synthesis / Christian F.W. Becker -- Using split inteins to prepare semi-synthetic proteins and to study the mechanism of protein trans-splicing / Henning D. Mootz -- Elucidation of the ras cycle with semi-synthetic proteins / Luc Brunsveld -- The study of rab GTpase recycling using semi-synthetic prenylated proteins / Kirill Alexandrov ... [et al.] -- Development of a model cancer vaccine candidate based on the MUC1 cellular surface glycopeptide epitope / Christian Hedberg and Ulrika Westerlind -- The introduction of chemical reporter groups by bioorthogonal ligation reactions for the imaging of cell-surface glycans / Rolf Breinbauer and Matthias Mental -- Sequence specific DNA-binding small molecules for protein recruitment and modulation of transcription / Hans-Dieter Arndt and Sascha Baumann -- G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulation / Barbara Sacca and Markus Kaiser

Summary: This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Books	Main library A9	Pharmacy ( Pharmacology )	547 C (Browse shelf(Opens below))	Available		00009162

Includes bibliographical references and index.

Yeast-based chemical genomic approaches / Katja Hubel --
Microarray-based strategies to identify unknown protein / Sabine Borgmann and Christof M. Niemeyer --
Compound collection synthesis for chemical biology / Kamal Kumar --
Target identification and validation of a WNT/P-catenin pathway modulator / Petra Janning --
Activity-based protein profiling of cys proteases / Renier van der Hoorn --
The use of photoaffinity labeling for the identification of the binding site of the antibiotic linezolid / Rolf Breinbauer and Matthias Mentel --
Surgical strikes : uses of analog sensitive technologies to target kinases of interest / Matthias Rabiller and Daniel Rauh --
Modulation of protein-protein interactions by small molecules / Stefanie Bovens and Christian Ottmann --
Targeted protein degradation in live cells / Markus Kaiser --
Trapoxin B : from total synthesis to epigenetics / Bruno Bulic --
Native chemical ligation : a tool for chemical protein synthesis / Christian F.W. Becker --
Using split inteins to prepare semi-synthetic proteins and to study the mechanism of protein trans-splicing / Henning D. Mootz --
Elucidation of the ras cycle with semi-synthetic proteins / Luc Brunsveld --
The study of rab GTpase recycling using semi-synthetic prenylated proteins / Kirill Alexandrov ... [et al.] --
Development of a model cancer vaccine candidate based on the MUC1 cellular surface glycopeptide epitope / Christian Hedberg and Ulrika Westerlind --
The introduction of chemical reporter groups by bioorthogonal ligation reactions for the imaging of cell-surface glycans / Rolf Breinbauer and Matthias Mental --
Sequence specific DNA-binding small molecules for protein recruitment and modulation of transcription / Hans-Dieter Arndt and Sascha Baumann --
G-quadruplex ligands as tools for elucidating c-MYC transcriptional regulation / Barbara Sacca and Markus Kaiser

This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion

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