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Protein discovery technologies / [edited by] Renata Pasqualini and Wadih Arap.

Contributor(s): Material type: TextTextSeries: Drug discovery series ; 12Publisher: Boca Raton : Taylor & Francis, [2009]Copyright date: ©2009Description: xv, 246 pages : illustrations (some color) ; 25 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 9780824754686 (hard back : alk. paper)
Subject(s): DDC classification:
  • 660.63 22 P
LOC classification:
  • TP248.65.P76 P728 2009
Online resources:
Contents:
Discovery of vascular permeability factor (VPF, VEGF, VPF/VEGF, VEGF-A165) / Harold F. Dvorak -- Tumor necrosis factor and its family members / Bharat B. Aggarwal, Alok C. Bharti, and Shishir Shishodia -- Blood-brain barrier models for investigating CNS pathologies / Pierre-Olivier Couraud and Sandrine Bourdoulous -- Identification of activation of latent TGF[beta] as principal in vivo function of integrin av[beta]6 / Dean Sheppard -- Purification of basic fibroblast growth factor by heparin affinity / Michael Klagsbrun and Yuen Shing -- How it came to pass that interferon was used as an angiogenesis inhibitor / Bruce R. Zetter -- Use of phage display to discover inhibitors of cell migration / Mikael Björklund, Michael Stefanidakis, Tanja-Maria Ranta, Aino Kangasniemi, Terhi Ruohtula, and Erkki Koivunen -- Combinatorial mapping of vascular zip codes by in vivo phage display / Renata Pasqualini and Wadih Arap -- Chasing elusive cellular prion protein receptor / Vilma R. Martins, Sandro J. De Souza, and Ricardo R. Brentani -- Discovery of molecular chaperone GRP78 and GRP94 inducible by endoplasmic reticulum stress / Amy S. Lee -- Origin of sphingomyelin pathway / Richard Kolesnick -- Endotoxin-induced myocarditis: A new pathophysiological entity in systemic inflammatory response syndrome / Ma-Li Wong and Julio Licinio -- Discovery of DOCK180 superfamily of exchange factors / Jean-François Côté and Kristiina Vuori -- Discovery of extracellular matrix degradome as novel endogenous regulators of angiogenesis and tumor growth / Lingge Lu, Tanjore Harikrishna, and Raghu Kalluri -- RING finger proteins as E3 ubiquitin ligases / Claudio A.P. Joazeiro and Tony Hunter -- Discovery of chemical nature of cross-links in collagen: A personal retrospective / Paul Bornstein -- Discovery of SPARC as prototype for matricellular proteins / E. Helene Sage.
Summary: A True Insider’s Guide to the Field – Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors’ past scientific achievements. Incorporates Short, Personal Discovery Vignettes Rather than an exhaustive field analysis, this globally pertinent resource presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control. This readily accessible resource discusses an array of interesting topics, including: Tumor necrosis factors The origin of interferon as an angiogenesis inhibitor In vivo combinatorial mapping of vascular zip codes Extracellular matrix degradome as regulators of angiogenesis and tumor growth A matricellular protein prototype The use of RING finger proteins as E3 Ubiquitin Ligases Whereas most books tend to be more specialized, this book contains a broad view of the protein discoveries in many different fields, making Protein Discovery Technologies a valuable reference for today’s researchers, both the new and more seasoned, who are seeking a newfound perspective or a deeper understanding of this exciting field. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
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Includes bibliographical references and index.

Discovery of vascular permeability factor (VPF, VEGF, VPF/VEGF, VEGF-A165) / Harold F. Dvorak --
Tumor necrosis factor and its family members / Bharat B. Aggarwal, Alok C. Bharti, and Shishir Shishodia --
Blood-brain barrier models for investigating CNS pathologies / Pierre-Olivier Couraud and Sandrine Bourdoulous --
Identification of activation of latent TGF[beta] as principal in vivo function of integrin av[beta]6 / Dean Sheppard --
Purification of basic fibroblast growth factor by heparin affinity / Michael Klagsbrun and Yuen Shing --
How it came to pass that interferon was used as an angiogenesis inhibitor / Bruce R. Zetter --
Use of phage display to discover inhibitors of cell migration / Mikael Björklund, Michael Stefanidakis, Tanja-Maria Ranta, Aino Kangasniemi, Terhi Ruohtula, and Erkki Koivunen --
Combinatorial mapping of vascular zip codes by in vivo phage display / Renata Pasqualini and Wadih Arap --
Chasing elusive cellular prion protein receptor / Vilma R. Martins, Sandro J. De Souza, and Ricardo R. Brentani --
Discovery of molecular chaperone GRP78 and GRP94 inducible by endoplasmic reticulum stress / Amy S. Lee --
Origin of sphingomyelin pathway / Richard Kolesnick --
Endotoxin-induced myocarditis: A new pathophysiological entity in systemic inflammatory response syndrome / Ma-Li Wong and Julio Licinio --
Discovery of DOCK180 superfamily of exchange factors / Jean-François Côté and Kristiina Vuori --
Discovery of extracellular matrix degradome as novel endogenous regulators of angiogenesis and tumor growth / Lingge Lu, Tanjore Harikrishna, and Raghu Kalluri --
RING finger proteins as E3 ubiquitin ligases / Claudio A.P. Joazeiro and Tony Hunter --
Discovery of chemical nature of cross-links in collagen: A personal retrospective / Paul Bornstein --
Discovery of SPARC as prototype for matricellular proteins / E. Helene Sage.

A True Insider’s Guide to the Field – Then and Now
Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors’ past scientific achievements.

Incorporates Short, Personal Discovery Vignettes

Rather than an exhaustive field analysis, this globally pertinent resource presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control.

This readily accessible resource discusses an array of interesting topics, including:

Tumor necrosis factors
The origin of interferon as an angiogenesis inhibitor
In vivo combinatorial mapping of vascular zip codes
Extracellular matrix degradome as regulators of angiogenesis and tumor growth
A matricellular protein prototype
The use of RING finger proteins as E3 Ubiquitin Ligases
Whereas most books tend to be more specialized, this book contains a broad view of the protein discoveries in many different fields, making Protein Discovery Technologies a valuable reference for today’s researchers, both the new and more seasoned, who are seeking a newfound perspective or a deeper understanding of this exciting field.

Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

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