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Medicinal chemistry : the role of organic chemistry in drug research / edited by C.R. Ganellin and S.M. Roberts.

Contributor(s): Material type: TextTextPublisher: London : Academic Press limited, [1993]Copyright date: c1993Edition: second editionDescription: xv, 302 pages : charts, illustartions (some color) ; 25 cmContent type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
ISBN:
  • 012274120X (alk. paper)
  • 9780122741203
  • 9789381269701 (hbk.)
Subject(s): DDC classification:
  • 22 615.7 M.
Contents:
1.Introduction to receptors and action of drugs -- 2.Structure and catalytic properties of enzymes -- 3. Receptor pharmacology -- 4. Drug access and prodrugs -- 5. Qsar and the role of computers in drug design -- 6.The current status and future impact of molecular biology in drug discovery -- 7.General approaches to discovering new drugs: An historical perspective -- 8. Discovery and development of cromakalim and related potassium channel activators -- 9. Angiotensin-converting enzyme (ACE) inhibitors and the design of cilazapril -- 10. Beta blockers -- 11. Salbutamol: a selective B2 - stimulant bronchodilator -- 12. Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists -- 13. Fluconazole, an orally active antifungal agent -- 14. Clavulanic acid and related compounds: inhibitors of B-lactamase enzymes
Summary: This book is aimed primarily at final year organic/medicinal chemists considering a research career in drug development. Recent exciting progress is reported in the chapters on individual drugs by their developers for the second edition of medicinal chemistry. In addition, this volume benefits from new chapters dealing with structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs.
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Holdings
Item type Current library Collection Call number Status Date due Barcode
Books Books Main library A11 Pharmacy ( Pharmaceutical chemistry ) 615.7 M. (Browse shelf(Opens below)) Available 00010380

Includes bibliographical references and index.

1.Introduction to receptors and action of drugs -- 2.Structure and catalytic properties of enzymes -- 3. Receptor pharmacology -- 4. Drug access and prodrugs -- 5. Qsar and the role of computers in drug design -- 6.The current status and future impact of molecular biology in drug discovery -- 7.General approaches to discovering new drugs: An historical perspective -- 8. Discovery and development of cromakalim and related potassium channel activators -- 9. Angiotensin-converting enzyme (ACE) inhibitors and the design of cilazapril -- 10. Beta blockers -- 11. Salbutamol: a selective B2 - stimulant bronchodilator -- 12. Discovery of cimetidine, ranitidine and other H2-receptor histamine antagonists -- 13. Fluconazole, an orally active antifungal agent -- 14. Clavulanic acid and related compounds: inhibitors of B-lactamase enzymes

This book is aimed primarily at final year organic/medicinal chemists considering a research career in drug development.
Recent exciting progress is reported in the chapters on individual drugs by their developers for the second edition of medicinal chemistry. In addition, this volume benefits from new chapters dealing with structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs.

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