Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.

Formerly CIP. |5 Uk

pharmacy bookfair2015

Includes bibliographical references and index.

Introduction to biopharmaceutics and pharmacokinetics --
Mathematic fundamentals in pharmacokinetics --
One-compartment open model: intravenous bolus administration --
Multicompartmental models : intravenous bolus administration --
Intravenous infusion --
Drug elimination and clearance --
Pharmacokinetics of oral absorption --
Multiple-dosage regimens --
Nonlinear pharmacokinetics --
Physiologic drug distribution and protein binding --
Drug elimination and hepatic clearance --
Pharmacogenetics --
Physiologic factors related to drug absorption --
Biopharmaceutic considerations in drug product design and in vitro drug product performance --
Drug product performance, in vivo : bioavailability and bioequivalence --
Impact of drug product quality and biopharmaceutics on clinical efficacy --
Modified-release drug products --
Targeted drug delivery systems and biotechnology products --
Relationship between pharmacokinetics and pharmacodynamics --
Application of pharmacokinetics to clinical situations --
Dosage adjustment in renal and hepatic disease --
Physiologic pharmacokinetic models, mean residence time, and statistical moment theory.

A textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics. It provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy.