TY  - BOOK
AU  - Padmanabhan,Sandosh
TI  - Handbook of pharmacogenomics and stratified medicines
SN  - 9780123868824
AV  - RM301.3.G45 H36 2014
U1  - 615.7 23
PY  - 2014///]
CY  - Amsterdam, Boston
PB  - Elsevier/AP, Academic Press is imprint of Elsevier
KW  - Pharmacogenetics
KW  - Individualized Medicine
N1  - pharmacy bookfair2016; Includes bibliographical references and index; Machine generated contents note: pt. I Introduction --
1.Pharmacogenomics and Stratified Medicine / Sandosh Padmanabhan --
1.1.Overview --
1.2.The Genetic Basis of Drug Response and Adverse Effects --
1.3.Single-Gene Studies --
1.4.Genome-Wide Association Studies in Pharmacogenomics --
1.5.The Road to Personalization and Stratification --
1.6.Pharmacogenetic Biomarkers and Companion Diagnostics --
1.7.Economic Challenges --
1.8.Conclusions --
References --
pt. II Basic Genetics --
2.Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws / Guan Wang --
2.1.Overview of the Cell: Anatomy, Components, and Function --
2.2.Cell Reproduction: Cell Cycle and Mitosis --
2.3.Meiosis --
2.4.Mendelian Laws --
2.5.Public Databases for Biomedical Research in Humans --
2.6.Conclusion --
Glossary --
Acknowledgments --
References --
3.The Human Genome, Gene Regulation, and Genomic Variation / Edward S. Tobias --
3.1.Overview: Structure of the Human Genome --
3.2.Gene Structures --
Contents note continued: 3.3.Gene Expression --
3.4.Gene Regulation --
3.5.Genomic Variation --
3.6.Conclusion --
References --
4.Epigenetics / Peter D. Adams --
4.1.Overview --
4.2.DNA Methylation --
4.3.Histones and Variants --
4.4.Epigenetic Disorders and Therapies --
4.5.Conclusion --
References --
pt. III Experimental and Discovery Platforms --
5.Animal Models in Pharmacogenomics / Delyth Graham --
5.1.Overview --
5.2.Rodent Models --
5.3.Nonrodent Models of Human Disease --
5.4.Genetic/Genomic Resources --
5.5.Ethical Issues of Animal Experimentation --
5.6.Caution and Limitations --
5.7.Applications of in vivo Models in Pharmacogenomic Research --
5.8.Rodent Models in Pharmacogenomics --
5.9.Conclusion --
References --
6.Human Lymphoblastoid Cell Lines in Pharmacogenomics / Jae-Pil Jeon --
6.1.Overview --
6.2.Generation of LCLs --
6.3.Biological Characteristics of LCLs --
6.4.Potentials and Limitations of LCL Applications --
6.5.Future Perspectives --
Acknowledgments --
Contents note continued: References --
7.Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches in Pharmacogenomic Studies / Federico Innocenti --
7.1.Overview --
7.2.Liver eQTL Studies --
7.3.Future Directions --
7.4.Conclusion --
Acknowledgments --
Glossary --
Acronyms and Abbreviations --
References --
8.Next-Generation Sequencing / Pawel Herzyk --
8.1.Overview --
8.2.First-Generation Sequencing: Chain Termination Method --
8.3.The Concept of Next-Generation Sequencing --
8.4.Application-Independent Data Analysis --
8.5.Genomic Applications --
8.6.Transcriptomic Applications --
8.7.Epigenomic Applications --
8.8.Metagenomic Applications
UR  - http://repository.fue.edu.eg/xmlui/handle/123456789/1828
ER  -