TY  - BOOK
AU  - Pearson,Paul G
AU  - Wienkers,Larry C
TI  - Handbook of Drug Metabolism
T2  - Drugs and the pharmaceutical sciences
SN  - 9780429190315
AV  - RM301.55 
U1  - 615.7 23
PY  - 2019///
CY  - [New York]
PB  - CRC Press
KW  - Drugs
KW  - Metabolism
KW  - Handbooks, manuals, etc
N1  - Includes bibliographical references and index; Section I: Fundamental Aspects of Drug Metabolism --
Chapter 1: The Evolution of Drug Metabolism Research --
Chapter 2: Pharmacokinetics of Drug Metabolites --
Chapter 3: The Cytochrome P450 Oxidative System --
Chapter 4: Aldehyde Oxidases an Emerging Group of Enzymes Involved in Xenobiotic Metabolism: Evolution, Structure, and Function --
Chapter 5: UDP-Glucuronosyltransferases --
Section II: Factors Which Affect Drug Metabolism --
Chapter 6: Non-CYP Drug Metabolizing Enzymes and Their Reactions --
Chapter 7: The Genetic Basis of Variation in Drug Metabolism and Toxicity --
Chapter 8: Inhibition of Drug Metabolizing Enzymes --
Chapter 9: Quantitative Approaches to Human Clearance Projection in Drug Research and Development --
Chapter 10: Sites of Extra Hepatic Metabolism, Part I: The Airways and Lung --
Chapter 11: Sites of Extra Hepatic Metabolism, Part II: Gut --
Chapter 12: Sites of Extra Hepatic Metabolism, Part III: Kidney --
Section III: Technologies to Study Drug Metabolism --
Chapter 13: Mass Spectrometry in Drug Metabolism Research: Principles and Common Practice --
Chapter 14: The Role of NMR as a Qualitative and Quantitative Analytical Technique in Biotransformation Studies --
Chapter 15: In Vitro Metabolism: Subcellular Fractions --
Chapter 16: Drug Interaction Studies in the Drug Development Process: Studies In Vitro --
Chapter 17: Enzyme Induction Studies in Drug Discovery and Development --
Chapter 18: Transporters in Drug Discovery and Development --
Chapter 19: Experimental Characterization of Cytochrome P450 Mechanism-Based Inhibition --
Section IV: Applications of Metabolism Studies in Drug Discovery and Development --
Chapter 20: Clinical Drug Metabolism --
Chapter 21: Managing Metabolic Activation Issues in Drug Discovery --
Chapter 22: Kinetic Differences between Generated and Preformed Metabolites: A Dilemma in Risk Assessment --
Chapter 23: Numerical Approaches to Drug Metabolism Kinetics and Pharmacokinetics --
Chapter 24: Active Metabolites in Drug Development --
Chapter 25: ADME of Antibody Drug Conjugates --
Chapter 26: Managing Reactive Metabolites in Drug Discovery and Development --
Chapter 27: Applications of 14C Accelerator Mass Spectrometry in Drug Development
UR  - https://doi.org/10.1201/9780429190315
ER  -