TY - BOOK AU - Ritschel,W.A. AU - Kearns,Gregory L TI - Handbook of basic pharmacokinetics-- including clinical applications SN - 0917330730 (pbk.) AV - RM301.5 .R57 1999 U1 - 615.7 21 PY - 1999/// CY - Washington, D.C. PB - American Pharmaceutical Association KW - Pharmacokinetics KW - Handbooks, manuals, etc KW - Handbooks N1 - Includes bibliographical references and index; 1. Definitions and glossary -- 2. LADMER system -- liberation, absorption, distribution, metabolism, elimination, and response -- 3. Organs, tissues, cells, and organelles -- 4. Cell membranes -- 5. Drug-receptor interactions -- 6. Absorption/transport mechanisms -- 7. pK[subscript a] and degree of ionization -- 8. Lipid/water partition coefficient -- 9. Physicochemical factors altering biological performance of drugs -- 10. Biopharmaceutical data of the gastrointestinal tract -- 11. Fluid compartments and circulatory system -- 12. Binding of drugs to biological material -- 13. Drug biotransformation -- 14. Compartment models -- 15. Determination of rate constants -- 16. Volume of distribution and distribution coefficient -- 17. Excretion and clearance of drugs -- 18. Urinary and biliary recycling -- 19. Cumulative urinary excretion -- 20. Area under the blood level-time curve -- 21. Pharmacokinetics of single dose administration -- 22. Pharmacokinetics of multiple dosing -- 23. Compartment model independent analysis -- 24. Pediatric pharmacokinetics -- 25. Drug dosage in elderly patients -- 26. Drug dosage in obese patients -- 27. Drug disposition in pregnancy -- 28. Dosage regimen design -- 29. Drug monitoring and dose adjustment -- 30. Physiological and pathological factors influencing drug response -- 31. First dose size in man -- 32. Forensic pharmacokinetics -- 33. Nonlinear pharmacokinetics -- 34. Curve fitting -- 35. Correlation of clinical response with drug disposition -- 36. Bioavailability and bioequivalence -- 37. Body surface areas -- 38. Extracorporeal methods of drug removal -- 39. Pharmacogenetics and pharmacogenomics ER -