TY  - BOOK
AU  - Mathiowitz,Edith
AU  - Chickering,Donald E
AU  - Lehr,Claus-Michael
TI  - Bioadhesive drug delivery systems: fundamentals, novel approaches, and development 
T2  - Drugs and the pharmaceutical sciences
SN  - 0824719956 (alk. paper)
AV  - RS201.B54 B567 1999
U1  - 615.58 21
PY  - 1999///]
CY  - New York
PB  - Marcel Dekker
KW  - Bioadhesive drug delivery systems
KW  - Drug Delivery Systems
KW  - Adhesiveness
N1  - Includes bibliographical references and index; I.Fundamentals of bioadhesion -- Definitions, mechanisms, and theories of bioadhesion -- The role of water movement and polymer hydration in mucoadhesion -- A rheological approach to explain the mucoadhesive behavior of polymer hydrogels -- Functional histology of epithelia relevant for drug delivery: respiratory tract, digestive tract, eye, skin, and vagina -- Biochemical and functional aspects of mucus and mucin-type glycoproteins -- II.Methods of evaluating bioadhesive interactions -- Adaptation of a microbalance to measure bioadhesive properties of microspheres -- Novel magnetic technique to measure bioadhesion -- Principles of skin adhesion and methods for measuring adhesion of transdermal systems -- Force microscopy of cells to measure bioadhesion -- Direct measurement of molecular-level forces and adhesion in biological systems -- A centrifugation method for measurement of two-dimensional binding characteristics of receptor-ligand interaction -- III.Novel concepts and strategies for bioadhesive drug delivery systems -- Multifunctional polymers for the peroral delivery of peptide drugs -- Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia -- Plant lectins for oral drug delivery to different parts of the gastrointestinal tract -- Bacterial invasion factors and lectins as second-generation bioadhesives -- Novel PEG-containing acrylate copolymers with improved mucoadhesive properties --Bioadhesive, bioerodible polymers for increased intestinal update -- IV.Development issues of bioadhesive drug delivery systems: products and clinical trials -- Novel formulation approaches to oral mucoadhesive drug delivery systems -- Bioadhesive formulations for nasal peptide delivery -- Development of bioadhesive buccal patches -- Vaginal delivery of calcitonin by hyaluronic acid formulations -- Ocular bioadhesive drug delivery systems -- bioadhesive preparations as topical dosage forms
ER  -