TY  - MANSCPT
AU  - Ibrahim,Enas El-Maghawry
TI  - A pharmaceutical study on colon-targeted delivery systems of an anti-inflammatory drug
U1  - 615.19 22
PY  - 2020///
KW  - Pharmaceutical industry
KW  - Pharmacology	
N1  - supervision of Prof. Dr. Ahmed Abd-Elbary (Professor of Pharmaceutics and Industrial Pharmacy, Ex-Dean of Faculty of Pharmacy, Cairo University, Beni Sweif University), Prof. Dr. Seham Elkheshen, (Professor of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University), Prof. Dr. Mina Ibrahim Tadros, (Professor of Pharmaceutics and Industrial Pharmacy, Dean of Faculty of Pharmacy and Drug Technology, Egyptian Chinese University); Thesis (Ph.D.)- Cairo university, Faculty of pharmacy, Department of Pharmaceutics and industrial Pharmacy, 2020; Includes bibliographical references
N2  - Colon-targeted drug delivery has been the focus of numerous studies  due to its potential to improve treatment of local diseases affecting the colon, while minimizing systemic drug side effects. Some examples of the diseases which impact the colon include Crohn’s disease (CD) and ulcerative colitis (UC). 
In literature, different strategies have been used to target the inflamed colon after oral drug administration. Strategies for specific colon drug delivery include the utilization of pro-drugs, exploitation of higher colonic pH values, and enzymatic activity of colonic micro flora, intestinal transit time and colonic pressure.
In general, dimensions of the delivery system greatly influence the targeting of the inflamed colon. Size-dependency of particles has a considerable impact on their epithelial uptake. A favoured accumulation in the inflamed colon tissues has been found for particles having sizes in the nanometer-range. It has been shown in experimental colitis models that nanosized particles are more readily uptaken by cells that are immune-related such as macrophages or dendritic cells in the site of active inflammation. 
The nano spray drying is one of the advanced technologies to produce nanoparticles. The nano spray dryer can produce relatively high yield of nanosized particles which possess narrow particle size distributions
UR  - http://repository.fue.edu.eg/xmlui/handle/123456789/5777
ER  -