TY  - BOOK
AU  - Abdelshaheed,Mennatallah Mahmoud
AU  - El-Subbagh,Hussein I.
AU  - Youssef,Khairia M.
AU  - Fawzy,Iten M.
TI  - Design, Synthesis and Biological Evaluation of New Fused  Piperidine Analogues as Anticancer Agents
U1  - 616.994061	 22
PY  - 2022///
KW  - Cancer
KW  - Treatment
KW  - Antineoplastic agents
KW  - Medicine
N1  - Supervisors : Prof. Dr. Hussein I. El-Subbagh,  Professor of Medicinal Chemistry,  Faculty of Pharmacy,  Mansoura University, Prof. Dr. Khairia M. Youssef,  Professor of Pharmaceutical Chemistry, Faculty of Pharmacy,  Future University in Egypt, Dr. Iten M. Fawzy,  Lecturer of Pharmaceutical Chemistry,  Faculty of Pharmacy,  Future University in Egypt; Thesis (M.Sc.)--Future University in Egypt, Faculty of pharmacy, Medicinal Chemistry, 2022; Includes bibliographical references (pages 104- 124)
N2  - Cancer is a serious health problem and is one of the leading causes of death worldwide. 
Piperidine is an essential pharmacophore and a favoured scaffold in the field of drug design. 
Piperidine nucleus exhibited great potential in chemotherapy. Previous studies have reported 
the antiproliferative effect of piperidine moiety against different cancer cell lines. Piperidine 
was found to be able to cause tubulin inhibition and induce apoptosis and cell cycle arrest in 
various types of cancer cells. In this thesis four different series of piperidine derivatives 
inspired by Curcumin were designed, synthesised, and tested in vivo and in vitro for their 
antitumor effect.
UR  - http://repository.fue.edu.eg/xmlui/handle/123456789/6062
ER  -