Methods for the discovery and characterization of G protein-coupled receptors - Stevens, Craig W. (New York : Humana Press, 2011)
In silico identification of novel G protein-coupled receptors / Alternative pre-mRNA splicing of G protein-coupled receptors / Detecting polymorphisms in G protein-coupled receptor genes / Regulation of the transcription of G protein-coupled receptor genes / Deciphering the evolution of G protein-coupled receptors in vertebrates / New approach to visualize endogenously expressed G protein-coupled receptors in tissues and living cells / Posttranslational regulation of G protein-coupled receptors / Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum / Identifying G protein-coupled receptor escorts, chaperones, and intracellular tethers regulating receptor density at the cell surface / Novel method for determining the kinetics of G protein-coupled receptor plasma membrane expression / Characterizing the pharmacology of G protein-coupled receptors in transfected cell lines / Novel assay technologies for the discovery of G protein-coupled receptor drugs / Discovering cell type-specific patterns of G protein-coupled receptor phosphorylation / Quantifying allosteric modulation of G protein-coupled receptors / Experimental designs for the study of receptor-receptor interactions / Elucidating agonist-selective mechanisms of G protein-coupled receptor desensitization / Detecting the role of arrestins in G protein-coupled receptor regulation / Characterizing molecular mobility and membrane interactions of G protein-coupled receptors / Using RNA interference to downregulate G protein-coupled receptors / Upregulating G protein-coupled receptors with receptor antagonists
Includes bibliographical references and index.
Keywords: G proteins; G proteins -- Receptors; GTP-Binding Proteins; Receptors, G-Protein-Coupled.