Antimicrobial drug discovery : emerging strategies - Tegos, George; Mylonakis, Eleftherios (Wallingford, Oxfordshire : CABI, 2012)
Emerging discovery strategies : an evolving necessity / Anthony R. Ball and George P. Tegos -- The antibiotic crisis / Arnold L. Demain and Jaroslav Spizek -- Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of escerichia coli and salmonella / Leonard Amaral ... [et al.] -- Small molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents / Sanjay M. Jachak ... [et al.] -- Fungal efflux-mediated resistance : from targets to inhibitors / Brian C. Monk ... [et al.] -- Vacuolar ATPase (V-ATPase) : a model proton pump for antifungal drug discovery -- Karlett J Parra -- Drug tolerance, persister cells and drug discovery / Kim Lewis -- Inhibition of quorum sensing as a novel antimicrobial strategy -- Gilles Brackman, Hans J. Nelis and Tom Coenye -- Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target / Jaroslaw M. Boberek ... [et al.] -- Lysostaphin : a silver bullet for staph / John F. Kokai-Kun -- Strategies to identify modified ribosomally synthesized antimicrobials -- Alan J. Marsh ... [et al.] -- QSAR based discovery of antimicrobial peptides active against multidrug resistant bacteria / Christopher D. Fjell ... [et al.] -- Acetyl-CoA carboxylase as a target for antibacterial development / Grover L. Waldrop -- Underexploited targets in LPS biogenenesis for the design of antibacterials / Laura Cipolla ... [et al.] -- Predicting and dissecting biomolecular interactions by information-driven docking / Panagiotis Kastritsis & Alexandre M.J.J Bonvin -- Anti-fungals and anti-fungal drug discovery / Richard Calderone ... [et al.] -- Pathosystematic studies and the rational design of antifungal interventions / Elaine M Bignell and Darius Armstrong-James -- In vivo high-throughput antimicrobial discovery screens utilizing caenorhabditis elegans as an alternative host / Jeffrey J. Coleman and Eleftherios Mylonakis -- Drosophila melanogaster as a versatile model for discovery of drugs effective against human microbe-induced infection and pathology / Yiorgos Apidianakis and Dimitrios P. Kontoyiannis -- Antimicrobial photosensitizers - harnessing the power of light to treat infections / Sulbha K Sharma, Tianhong Dai and Michael R Hamblin -- Nanoparticle platforms for antimicrobial therapy / David Trofa, Joshua D. Nosanchuk -- Antimicrobial activity of carbon nanotubes / Shaobin Liu, Yuan Chen.
Includes bibliographical references and index.
Keywords: Anti-Infective Agents -- pharmacology; Drug Design; Disease Models, Animal; High-Throughput Screening Assays -- methods; Photosensitizing Agents -- pharmacology