TY - BOOK AU - Shargel,Leon AU - Wu-Pong,Susanna AU - Yu,Andrew B.C. TI - Applied biopharmaceutics & pharmacokinetics SN - 9781259011115 U1 - 615.7 22 PY - 2005/// CY - New York, London PB - McGraw-Hill KW - Biopharmaceutics KW - Pharmacokinetics KW - Models, Chemical N1 - Formerly CIP. |5 Uk; pharmacy bookfair2015; Includes bibliographical references and index; Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory N2 - A textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics. It provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy ER -