The molecular basis of cancer / John Mendelsohn, MD, Director, Khalifa Institute for Personalized Cancer Therapy and Past President, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; Joe W. Gray, PhD, Gordon Moore Endowed Chair, Chairman, Department of Biomedical Engineering, Director, OHSU Center for Spatial Systems Biomedicine, Associate Director for Translational Research, Knight Cancer Institute, Oregon Health and Science University (OHSU), Portland, Oregon; Peter M. Howley, MD, Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachesetts; Mark A. Israel, MD, Director, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, Professor of Pediatrics and Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; Craig B. Thompson, MD, President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York.

Includes bibliographical references and index.

Cancer: A Genetic Disorder --
Oncogenes and Signal Transduction --
Tumor Suppressor Genes --
DNA Repair Pathways and Human Cancer --
Epigenetics and Cancer --
Infectious Agents and Cancer --
Environmental Carcinogenesis --
Animal Models: Flies, Fish, and Yeast --
Genetic Mouse Models of Cancer --
Cancer Stem Cells and the Microenvironment --
Regulation of the Cell Cycle --
Cell Growth --
The Metabolism of Cell Growth and Proliferation --
Apoptosis, Necrosis, and Autophagy --
Cellular Senescence --
The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis --
Tumor Angiogenesis --
Invasion and Metastasis --
Inflammation and Cancer --
Cancer Systems Biology: The Future --
Biomarkers for Assessing Risk of Cancer --
Protein Biomarkers for Detecting Cancer: Molecular Screening --
The Technology of Analyzing Nucleic Acids in Cancer --
Understanding and Usin

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice.