Biodegradable hydrogels for drug delivery / Kinam Park, Waleed S.W. Shalaby, Haesun Park

Includes bibliographical references and index

Chapters, sub-chapters and selected sub-sections, some condensed for this space. All chapters end with a section of References. Introductiono Controlled Release Drug Delivery Systems o Hydrogels: Definition, Hydrogel as a Biomaterial, Biodegradable Hydrogels Biodegradationo Definitions: Bioresorption, Bioabsorption, Bioerosion, Biodeterioration o Mechanisms: Solubilization, Charge Formation Followed by Dissolution o Chemical Hydrolysis of Polymers:Enzyme-Catalyzed Hydrolysis o Biodegradable Hydrogels Types of Biodegradable Hydrogelso Hydrogels with Degradable Polymer Backbone: Crosslinked Hydrogels, Noncrosslinked Hydrogels o Hydrogels with Degradable Crosslinking Agents: Crosslinked with Small Molecules, Crosslinked with Oligopeptides, Crosslinked with Macromolecules o Hydrogels with Degradable Pendant Chains Chemical Gelso Polymerization in the Presence of Crosslinking Agents: Introduction of Double Bonds to Macromolecules, Determination of Double Bonds on the Macromonomers o Crosslinking of Water-Soluble Polymers: Crosslinking with Functional Groups, Nonspecific Crosslinking, Determination of the Degree of Crosslinking Physical Gelso Thermoreversible Gelling System: Gels with Thermomelting Properties,Gels with Thermogelation Properties o Thermoreversible Gelling Polysaccharides: Water-Soluble Polysaccharides, Gel-Forming Polysaccharides o Physical Gelation by Ion Complexation: Polymers with Hydroxyl Groups, Carrageenan, Gellan, Pectin, Alginate, Polyphosphazenes, Other Polyanions, Chitosan o Physical Gelation by Specific Interactions: Fibrin Gel, Mucus Gel, Actin Gel, Avidin-Biotin Mediated Gel, Antibody Mediated Gel, Lectin-Mediated Gel oDetermination of the Crosslink Density Chemically-Induced Degradationo Chemically-Induced Hydrolysis in the Body: Distribution and Elimination, Factors Influencing Chemically-Induced Hydrolysis o Chemically-Induced Hydrolysis of Polyesters: Poly(glycolic Acid), Poly(lactic Acid), Polycaprolactone, Poly(ethylene Terephthalate), Poly(ss-hydroxybutyrate), Polydioxanone o Polyester Hydrogels Enzyme-Catalyzed Degradationo Properties of Enzymes o Hydrolytic Enzymes in the Body: Gastrointestinal Tract, Reticuloendothelial System, Others o Factors Influencing Enzyme-Catalyzed Reactions: Conformation of Enzymes and Substrates, Presence of Polymer Molecules o Enzyme-Catalyzed Degradation of Modified Proteins: Albumin, Gelatin, Modified Enzymes o Enzyme-Catalyzed Degradation of Modified Polysaccharides: Dextran, Starch, Amylose, Chitosan, Chondroitin-6-Sulfate Biodegradable Drug Delivery Systemso Mechanisms of Drug Release: Diffusion-Controlled Systems, Swelling-Controlled Systems, Biodegradable Systems o Drug Release From Hydrogels with Biodegradable Backbones: Hydrogels Based on Protein/Polypeptides, Hydrogels Based on Polysaccharides, Biodegradable Hydrogels Based on Polyesters o Drug Release From Hydrogels with Degradable Crosslinking Agents: Hydrogels Crosslinked with Small Molecules, Hydrogels Crosslinked with Albumin o Drug Release from Hydrogels with Biodegradable Pendant Chains Future Developmento Drug Loading o Drug Targeting o Drug Releaseo Degradation and Elimination o Use of Bioactive Polymers