Natural products in medicinal chemistry / edited by Stephen Hanessian.

pharmacy bookfair2016

Includes bibliographical references and index.

Natural products as drugs and leads to drugs: an introduction and perspectives as of the end of 2012 -- Natural product-derived and natural product-inspired compound collections -- Chemistry and biology of epothilones -- Taxol, taxoids, and related taxanes -- Camptothecin and analogs -- A short history of the discovery and development of naltrexone and other morphine derivatives -- Lincosamide antibacterials -- Platensimycin and platencin -- From natural product to new diabetes therapy: phlorizin and the discovery of SGLT2 inhibitor clinical candidates -- Aeruginosins as thrombin inhibitors -- Macrolides and antifungals via biotransformation -- Unnatural nucleoside analogs for antisense therapy -- Hybrid natural products -- Rethinking the role of natural products: function-oriented synthesis bryostatin, and bryologs -- Cyclopamine and congeners -- Hybrids, congeners, mimics and constrained variants spanning 30 years of natural products chemistry: a personal retrospective.

The inspiration provided by biologically active natural
products to conceive of hybrids, congeners, analogs and
unnatural variants is discussed by experts in the field in 16
highly informative chapters.
Using well-documented studies over the past decade, this
timely monograph demonstrates the current importance
and future potential of natural products as starting points for
the development of new drugs with improved properties
over their progenitors.
The examples are chosen so as to represent a wide range
of natural products with therapeutic relevance among
others, as anticancer agents, antimicrobials, antifungals,
antisense nucleosides, antidiabetics, and analgesics

Also issued online.