000 03325cam a2200433 i 4500
999 _c10154
_d10154
001 862761681
005 20230521111130.0
008 130912s2014 gw a b 001 0 eng d
015 _aGBB3A2305
_2bnb
020 _a9783527332182 (hbk.)
020 _a3527332189 (hbk.)
020 _z9783527676552 (ePDF)
035 _a(OCoLC)862761681
_z(OCoLC)858361663
040 _aUKMGB
_beng
_cUKMGB
_dOCLCO
_dBDX
_dOHX
_dCDX
_dIXA
_dBTCTA
_dYDXCP
_dMXC
_erda
082 0 4 _a615.19
_223
_bN
245 0 0 _aNatural products in medicinal chemistry /
_cedited by Stephen Hanessian.
264 1 _aWeinheim :
_bWiley-VCH,
_c[2014]
300 _axxi, 630 pages :
_billustrations ;
_c24 cm.
336 _atext
_btxt
_2rdacontent.
337 _aunmediated
_bn
_2rdamedia.
338 _avolume
_bnc
_2rdacarrier.
490 1 _aMethods and principles in medicinal chemistry ;
_vvolume 60.
500 _apharmacy bookfair2016
504 _aIncludes bibliographical references and index.
505 0 _aNatural products as drugs and leads to drugs: an introduction and perspectives as of the end of 2012 -- Natural product-derived and natural product-inspired compound collections -- Chemistry and biology of epothilones -- Taxol, taxoids, and related taxanes -- Camptothecin and analogs -- A short history of the discovery and development of naltrexone and other morphine derivatives -- Lincosamide antibacterials -- Platensimycin and platencin -- From natural product to new diabetes therapy: phlorizin and the discovery of SGLT2 inhibitor clinical candidates -- Aeruginosins as thrombin inhibitors -- Macrolides and antifungals via biotransformation -- Unnatural nucleoside analogs for antisense therapy -- Hybrid natural products -- Rethinking the role of natural products: function-oriented synthesis bryostatin, and bryologs -- Cyclopamine and congeners -- Hybrids, congeners, mimics and constrained variants spanning 30 years of natural products chemistry: a personal retrospective.
520 _aThe inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics
530 _aAlso issued online.
650 0 _aNatural products.
650 0 _aOrganic compounds
_xSynthesis.
_912540
650 0 _aPharmaceutical chemistry.
650 1 2 _aBiological Products.
_98631
650 1 2 _aChemistry, Pharmaceutical.
700 1 _aHanessian, Stephen,
_eeditor of compilation.
830 0 _aMethods and principles in medicinal chemistry ;
_vvolume 60.
856 _uhttp://dspace.fue.edu.eg:8080/jspui/bitstream/123456789/217/1/Natural%20products%20in%20medicinal%20chemistry.pdf
_ySummry As PDF
856 _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1792
_3Abstract
942 _2ddc
_cBK