000			03983cam a2200613 i 4500
999			_c10198 _d10198
001			18409641
005			20190422103723.0
008			141217t20152015enka b 001 0 eng c
010			_a 2014434400
015			_aGBB282750 _2bnb
016	7		_a101649799 _2DNLM
020			_a9781849731867 (hb)
020			_a1849731861
020			_z9781849735087
035			_a(OCoLC)ocn896613655
040			_aNLM _beng _cNLM _erda _dNLE _dYDXCP _dZWZ _dOCLCF _dOCLCO _dDLC
042			_apcc
050	0	0	_aRM301.25 _b.I59 2015
060	0	0	_a2015 A-381
060	1	0	_aQV 745
082	0	0	_a615.19 _222 _bI
245	0	0	_aIon channel drug discovery / _cedited by Brian Cox, Martin Gosling, Horsham Research Centre, Horsham, UK.
260			_aCambridge : _bRoyal Society of Chemistry, _cc2015.
300			_axviii, 366 p. : _bill. ; _c25 cm.
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
490	1		_aRSC drug discovery series, _x2041-3203 ; _vno. 39
500			_a"The Queen's Awards for Enterprise: International Trade 2013."
500			_apharmacy bookfair2016
504			_aIncludes bibliographical references and index.
505	0		_aIon channel drug discovery: a historical perspective / Brian Cox -- High-throughput screening / Alexander Böcker, Sabine Schaertl and Stephen D. Hess -- Automated electrophysiology in ion channel drug discovery / John Dunlop -- Structural understanding of ion channels in atomic detail / Phillip J. Stansfeld -- Voltage-gated sodium channels: structure, function, and molecular pharmacology / William A. Catterall -- AMPA receptor positive allosteric modulators: a case history / Simon E Ward -- The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease / Catherine Howsham and Henry Danahay -- The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel / Jia Liu, Gerta Cami-Kobeci, Yiting Wang, Pissared Khuituan, Zhiwei Cai, Hongyu Li, Stephen M. Husbands and David N. Sheppard -- TRPV1 antagonism: from research to clinic / Mark S. Nash, J. Martin Verkuyl and Gurdip Bhalay -- Open access to the KCNQ channel: retigabine and second generation M-current openers / Johannes Krupp, Anthony M. Rush, Britt-Marie Swahn and Martin Main -- The therapeutic potential of hERG1 K+ channels for treating cancer and cardiac arrhythmias / John Mitcheson and Annarosa Arcangeli -- Does nature do ion channel drug discovery better than us? / Richard J. Lewis, Irina Vetter, Fernanda C. Cardoso, Marco Inserra and Glenn King -- Antibodies as ion channel modulators / Wilson Edwards and Alan D. Wickenden -- Ion channel drug discovery: future perspectives / Martin Gosling.
520			_aA rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.
650		0	_aPharmaceutical chemistry.
650		0	_aDrug development.
650		0	_aIon channels.
650	1	2	_aDrug Discovery.
650	2	2	_aIon Channels _xchemistry.
650		7	_aDrug development. _2fast _0(OCoLC)fst00898670
650		7	_aIon channels. _2fast _0(OCoLC)fst00978573
650		7	_aPharmaceutical chemistry. _2fast _0(OCoLC)fst01060115
650		7	_aChimie pharmaceutique. _2ram
650		7	_aMédicaments _xMise au point. _2ram
650		7	_aCanaux ioniques. _2ram
700	1		_aCox, Brian _c(Chemist), _eeditor.
700	1		_aGosling, Martin, _eeditor.
710	2		_aRoyal Society of Chemistry (Great Britain), _eissuing body. _97549
830		0	_aRSC drug discovery series ; _v39. _x2041-3203
856	4	1	_3Abstract _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1800
906			_a7 _bcbc _cpccadap _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK