000			04937cam a22005295i 4500
999			_c10344 _d10344
001			18409495
003			OSt
005			20190506114918.0
008			141217s2015 ne a b 001 0 eng
010			_a 2014959674
016	7		_a101663559 _2DNLM
020			_a9780124115088 (paperback)
020			_a012411508X (paperback)
020			_z9780124115255 (PDF ebook)
035			_a(OCoLC)ocn910976178
040			_aNLM _beng _cNLM _erda _dNLGGC _dYDXCP _dZWZ _dBTCTA _dLTSCA _dCDX _dIAX _dOCLCF _dDLC
042			_anlmcopyc _alccopycat
050	0	0	_aRM301.25 _b.B59 2015
060	0	0	_a2015 G-397
060	1	0	_aQV 745
082	0	4	_a615.19 _223 _bB.B.B
100	1		_aBlass, Benjamin E., _eauthor.
245	1	0	_aBasic principles of drug discovery and development / _cBenjamin E. Blass, Temple University School of Pharmacy, Moulder Center for Drug Discovery Research, North Broad Street, Philadelphia, PA, USA.
264		1	_aAmsterdam ; _aBoston : _bElsevier/AP, Academic Press is an imprint of Elsevier, _c[2015]
300			_axv, 574 pages : _billustrations ; _c23 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
500			_apharmacy bookfair2016
504			_aIncludes biblographical references and indexes.
505	0		_a Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 -- Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 -- The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 -- Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 -- In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 -- Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS THE PHARMACOPHOREDEVELOPING AN SAR DATA SET; THE STRUCTURE-ACTIVITY RELATIONSHIP CYCLE; BIOISOSTERISM; STRUCTURE-ACTIVITY RELATIONSHIP, SELECTIVITY AND PHYSICOCHEMICAL PROPERTIES; "DRUGLIKE" GUIDELINES; QUESTIONS; References; Chapter 6 -- In vitro ADME and In vivo Pharmacokinetics; ABSORPTION; DISTRIBUTION; ELIMINATION PATHWAYS; IN VITRO ADME SCREENING METHODS; IN VIVO PHARMACOKINETICS; SPECIES SELECTION; QUESTIONS; References; Chapter 7 -- Animal Models of Disease States; SOURCES OF ANIMAL MODELS; VALIDITY OF ANIMAL MODELS; SPECIES SELECTION; NUMBER OF ANIMALS EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 -- Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 -- Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY
650		0	_aDrug development.
650		0	_aDrugs _xDesign.
650	1	2	_aDrug Discovery.
650	2	2	_aDrug Evaluation.
650		7	_aDrug development. _2fast _0(OCoLC)fst00898670
650		7	_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790
650		7	_aChimie pharmaceutique. _2ram
650		7	_aChimie bioorganique. _2ram
650		7	_aPharmacologie moléculaire. _2ram
650		7	_aMédicaments _xConception. _2ram
856			_3Abstract _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1807
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK