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008			140801t20142014ne a b 001 0 eng c
010			_a 2014381918
016	7		_a101635605 _2DNLM
016	7		_a016747418 _2Uk
020			_a9780123868824
020			_a0123868823
035			_a(OCoLC)ocn882610084
040			_aNLM _beng _cNLM _erda _dUKMGB _dDLC
042			_apcc
050	0	0	_aRM301.3.G45 _bH36 2014
060	0	0	_aQV 38.5
082	0	0	_a615.7 _223 _bH
245	0	0	_aHandbook of pharmacogenomics and stratified medicines / _cedited by Sandosh Padmanabhan, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
264		1	_aAmsterdam ; _aBoston : _bElsevier/AP, Academic Press is imprint of Elsevier, _c[2014]
264		4	_c©2014
300			_axxiii, 1093 pages : _billustrations ; _c29 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
500			_apharmacy bookfair2016
504			_aIncludes bibliographical references and index.
505	0		_aMachine generated contents note: pt. I Introduction -- 1.Pharmacogenomics and Stratified Medicine / Sandosh Padmanabhan -- 1.1.Overview -- 1.2.The Genetic Basis of Drug Response and Adverse Effects -- 1.3.Single-Gene Studies -- 1.4.Genome-Wide Association Studies in Pharmacogenomics -- 1.5.The Road to Personalization and Stratification -- 1.6.Pharmacogenetic Biomarkers and Companion Diagnostics -- 1.7.Economic Challenges -- 1.8.Conclusions -- References -- pt. II Basic Genetics -- 2.Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws / Guan Wang -- 2.1.Overview of the Cell: Anatomy, Components, and Function -- 2.2.Cell Reproduction: Cell Cycle and Mitosis -- 2.3.Meiosis -- 2.4.Mendelian Laws -- 2.5.Public Databases for Biomedical Research in Humans -- 2.6.Conclusion -- Glossary -- Acknowledgments -- References -- 3.The Human Genome, Gene Regulation, and Genomic Variation / Edward S. Tobias -- 3.1.Overview: Structure of the Human Genome -- 3.2.Gene Structures -- Contents note continued: 3.3.Gene Expression -- 3.4.Gene Regulation -- 3.5.Genomic Variation -- 3.6.Conclusion -- References -- 4.Epigenetics / Peter D. Adams -- 4.1.Overview -- 4.2.DNA Methylation -- 4.3.Histones and Variants -- 4.4.Epigenetic Disorders and Therapies -- 4.5.Conclusion -- References -- pt. III Experimental and Discovery Platforms -- 5.Animal Models in Pharmacogenomics / Delyth Graham -- 5.1.Overview -- 5.2.Rodent Models -- 5.3.Nonrodent Models of Human Disease -- 5.4.Genetic/Genomic Resources -- 5.5.Ethical Issues of Animal Experimentation -- 5.6.Caution and Limitations -- 5.7.Applications of in vivo Models in Pharmacogenomic Research -- 5.8.Rodent Models in Pharmacogenomics -- 5.9.Conclusion -- References -- 6.Human Lymphoblastoid Cell Lines in Pharmacogenomics / Jae-Pil Jeon -- 6.1.Overview -- 6.2.Generation of LCLs -- 6.3.Biological Characteristics of LCLs -- 6.4.Potentials and Limitations of LCL Applications -- 6.5.Future Perspectives -- Acknowledgments -- Contents note continued: References -- 7.Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches in Pharmacogenomic Studies / Federico Innocenti -- 7.1.Overview -- 7.2.Liver eQTL Studies -- 7.3.Future Directions -- 7.4.Conclusion -- Acknowledgments -- Glossary -- Acronyms and Abbreviations -- References -- 8.Next-Generation Sequencing / Pawel Herzyk -- 8.1.Overview -- 8.2.First-Generation Sequencing: Chain Termination Method -- 8.3.The Concept of Next-Generation Sequencing -- 8.4.Application-Independent Data Analysis -- 8.5.Genomic Applications -- 8.6.Transcriptomic Applications -- 8.7.Epigenomic Applications -- 8.8.Metagenomic Applications...
650		0	_aPharmacogenetics. _98471
650	1	2	_aPharmacogenetics. _98471
650	2	2	_aIndividualized Medicine.
700	1		_aPadmanabhan, Sandosh, _eeditor of compilation.
856			_3Abstract _uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1828
906			_a7 _bcbc _cpccadap _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK