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020 _a18715125 (series)
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050 0 0 _aRS189
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060 0 0 _aQV 740 AA1
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_223
_bP
245 0 0 _aProfiles of drug substances, excipients, and related methodology /
_cHarry G. Brittain.
260 _aAmsterdam ;
_bElsevier Academic Press,
_cc2014.
300 _av. :
_bill. ;
_c24 cm.
310 _aAnnual
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
500 _aIncludes index.
500 _apharmacy bookfair2016
505 0 _aFront Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface to Volume 39; Chapter One: Azithromycin; Background; 1. Description; 1.1. Nomenclature; 1.1.1. Systematic chemical names [2-5]; 1.1.2. Nonproprietary names; 1.1.3. Proprietary names [3,7,8]; 1.2. Formulae[2,3]; 1.2.1. Empirical formula, molecular weight, CAS number; 1.2.2. Structural formula; 1.3. Elemental analysis; 1.4. Appearance [2]; 2. Methods of Preparation of Azithromycin; 3. Physical Characteristics; 3.1. Specific optical rotation [5,21]; 3.2. Ionization constant [22]. 3.3. Solubility characteristics [21]3.4. Partition coefficient; 3.5. Particle morphology; 3.6. Crystallographic properties; 3.6.1. Single crystal structure; 3.6.2. X-ray powder diffraction pattern [28]; 3.7. Hygroscopicity; 3.8. Thermal methods of analysis; 3.8.1. Melting behavior; 3.8.2. Differential scanning calorimetry [25]; 3.8.3. Thermogravimetric analysis; 3.8.4. Karl Fischer titration (KFT) [25]; 3.8.5. Boiling point, enthalpy of vapor, flash point, and vapor pressure; 3.9. Spectroscopy; 3.9.1. UV/Vis spectroscopy; 3.9.2. Vibrational spectroscopy [32]. 3.9.3. Nuclear magnetic resonance spectrometry [33]3.9.3.1. 1H NMR spectrum [33]; 3.9.3.2. 13C NMR spectrum [33]; 3.10. Mass spectrometry [34]; 4. Methods of Analysis; 4.1. Compendial methods of analysis; 4.1.1. Identification; 4.1.1.1. IR spectrum of Azithromycin; 4.1.1.2. HPLC drug chromatogram; 4.1.2. Impurity Analysis [47]; 4.1.3. Other tests; 4.1.3.1. Water [47]; 4.1.3.2. Sulphated ash [47]; 4.1.4. Assay method [47]; 4.1.4.1. Liquid chromatography; 4.2. Electrochemical methods of analysis; 4.2.1. Voltammetry; 4.2.2. Coulometry; 4.3. Spectroscopic methods of analysis. 4.3.1. Spectrophotometry4.3.2. Spectrofluorimetry; 4.3.3. Colorimetry; 4.4. Chromatographic methods of analysis; 4.4.1. Electrophoresis; 4.4.2. Thin-layer chromatography; 4.4.3. High-performance liquid chromatography; 4.5. Determination in body fluids and tissues; 5. Stability; 6. Clinical Applications; 6.1. An overview; 6.2. Antimicrobial spectrum susceptibility; 6.3. Mechanism of action; 6.4. Resistance to macrolides; 6.5. Actions other than antimicrobial effects; 6.6. Clinical uses and dosing; 6.7. ADME profile; 6.8. Side effects; 6.9. Drug interactions; References; Chapter Two: Cefdinir. 1. Description1.1. Nomenclature; 1.1.1. Systematic chemical names; 1.1.2. Non-proprietary names; 1.1.3. Proprietary names; 1.2. Formulae; 1.2.1. Empirical formula, molecular weight, and CAS number; 1.2.2. Structural formula; 1.3. Elemental analysis; 1.4. Appearance; 2. Uses and Applications; 3. Methods of Preparation; 4. Physical Characteristics; 4.1. Ionization constant; 4.2. Solubility; 4.3. X-ray powder diffraction; 4.4. Thermal methods of analysis; 4.4.1. Melting point; 4.4.2. Differential scanning calorimetry; 5. Spectral Properties; 5.1. Ultraviolet spectroscopy.
520 _aVolumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.
650 0 _aDrugs
_xAnalysis
_vPeriodicals.
_98548
650 0 _aExcipients
_xAnalysis
_vPeriodicals.
650 2 _aExcipients
_xanalysis
_vPeriodicals.
650 2 2 _aExcipients
_xchemistry
_vPeriodicals.
_98552
650 2 _aExcipients
_xpharmacokinetics
_vPeriodicals.
_98553
650 2 _aPharmaceutical Preparations
_vPeriodicals.
_98554
650 2 _aPharmaceutical Preparations
_xanalysis
_vPeriodicals.
_98555
650 2 _aPharmaceutical Preparations
_xchemistry
_vPeriodicals.
_98556
650 2 _aPharmacokinetics
_vPeriodicals.
650 6 _aMédicaments
_xAnalyse
_vPériodiques.
_98558
650 6 _aExcipients
_xAnalyse
_vPériodiques.
_98559
650 7 _aExcipients.
_2fmesh
650 7 _aPréparations pharmaceutiques
_xanalyse.
_2fmesh
_98561
650 7 _aPharmacocinétique.
_2fmesh
_98562
700 1 _aBrittain, Harry G.
_eeditor
856 _3Abstract
_uhttp://repository.fue.edu.eg/xmlui/handle/123456789/1840
942 _2ddc
_cBK