| 000 | 03885ntm a2200361 i 4500 | ||
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| 001 | 12102116 | ||
| 005 | 20230824142907.0 | ||
| 008 | 150118s2014 ua a frmb 000 0 eng c | ||
| 040 |
_aEG-NcFUE _erda |
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| 041 | 0 |
_aeng _bara |
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| 082 | 0 | 4 |
_a615.19 _bF.A.S _221 |
| 100 | 1 |
_aFouly, Aya Mohamed Adel Abdel Halim. _eauthor |
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| 245 | 1 | 0 |
_aStudy of the effect of lubricants on the physicochemical properties of certain polymeric films / _cAya Mohamed Adel Abdel Halim Fouly ; Supervisors Hussein Ammar, Mamdouh Ghorab, Shadid Gad Abdulrahman. |
| 246 | 3 | 5 | _aدراسة عن تاثير موانع الالتصاق على الخواص |
| 264 | 1 | _c2014. | |
| 300 |
_a306 pages : _billustrations ; _c24 cm. |
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| 336 |
_atext _2rdacontent |
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| 337 |
_aunmediated _2rdamedia |
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| 338 |
_avolume _2rdacarrier |
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| 500 | _aSupervisor : Hussein Amaar. | ||
| 502 | _aThesis (M.Sc)-Suez Canal university, Faculty of pharmacy, Department of Pharmaceutics, 2014. | ||
| 504 | _aIncludes bibliographical references. | ||
| 520 | _aSolid dosage forms represent a great share of the pharmaceutical production due<br>to being; stable, easier for shipping and handling and have longer expiration<br>dates. In addition, solid dosage forms require less shelf space, do not require<br>preservation and have accurate dosage (single dose).<br>Coating represents a very important operation during the production of solid<br>dosage forms either due to enhancing tablet flowability and line clearance or due<br>to functional and patient adherence related issues.<br>Polymeric film coating is CHARacterized over other coating methodologies by its<br>quality, operational efficiency, safety and profit. Aqueous-based systems have<br>gained popularity over solvent-based systems due to their lower toxicity levels<br>and environment friendly standpoint.<br>Eudragit® acrylic resins have been widely used in the pharmaceutical industry,<br>they are CHARacterized by being water insoluble but swellable polymers.<br>Antiadherents are very common additives during aqueous acrylic polymeric<br>film coating so as to avoid susceptible stickiness or tackiness of polymeric films<br>which is a concern during both coating process and storage.<br>Talc is considered to be one of the most frequently used antiadherents specially<br>in the Egyptian market due to its low price and is CHARacterized by its<br>hydrophobic nature, Glyceryl monostearate (GMS) has been used as an<br>alternative for talc and is known by its waxy nature. The ready-to-use<br>PlasacrylTM T20 suspension which contains GMS as an antiadherent, triethyl<br>Abstract<br>ii<br>citrate as a plasticizer and polysorbate 80 as a surfactant has been recently used<br>with Eudragit® polymers.<br>In spite of being a corner stone in the treatment of the unwanted tablet<br>agglomeration during coating, antiadherents may be causative factor for many<br>changes in either the physicochemical properties or the dissolution properties of<br>acrylic polymeric film coating systems.<br>Polymer films must be mechanically strong such that they do not break or<br>fracture during processing, packaging, shipping, and storage.<br>Generally, particles coated with a film behave differently from the film itself.<br>However, there is no doubt that studies conducted on free films help to<br>understand the behavior of dosage forms coated with these films. Free films can<br>be obtained by the casting method, where a polymeric solution or dispersion is<br>cast onto a n | ||
| 546 | _aText in English, abstracts in English and Arabic. | ||
| 650 | 4 | _aPharmaceutics | |
| 650 | 4 | _aPolymers in medicine. | |
| 650 | 4 | _aPolymers | |
| 650 | 4 | _aBiomedical materials | |
| 700 | 1 |
_aGhorab, Mamdouh _eSupervisor. _cProf. Dr |
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| 700 | 1 |
_aAmmar, Hussein, _eSupervisor. _cProf. Dr |
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| 700 | 1 |
_aAbdualrahman, Shadid Gad _eSupervisor. _cProf. Dr |
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| 942 | _cTHESIS | ||
| 999 |
_c10863 _d10863 |
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