000			02689cam a22004218i 4500
999			_c11234 _d11234
001			18577358
005			20171029144121.0
008			150415s2016 nyu b 001 0 eng
010			_a 2015014810
020			_a9789814670241
020			_a9814670243
035			_a(DNLM)101656208
040			_aDNLM/DLC _beng _erda _cDLC
042			_apcc
050	0	0	_aRM301.4
060	1	0	_aQV 38
082	0	0	_a615.7 _bS.L.A _223
100	1		_aShargel, Leon, _d1941- , _eauthor.
245	1	0	_aApplied biopharmaceutics & pharmacokinetics / _cLeon Shargel, Andrew B.C. Yu.
246	1		_aApplied biopharmaceutics and pharmacokinetics
250			_aSeventh edition.
263			_a1511
264		1	_aNew York : _bMcGraw-Hill Education, _c[2016]
300			_axvii, 910 p. : _billustrations ; _c24 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.
520	0		_aThe landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics-now fully updated
650	1	2	_aBiopharmaceutics.
650	1	2	_aPharmacokinetics.
650	2	2	_aDrug Administration Routes.
650	2	2	_aModels, Chemical.
700	1		_aYu, Andrew B. C., _d1945- , _eauthor.
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cREF