000			03139nam a22003137i 4500
999			_c11660 _d11660
005			20190424114329.0
008			190424s2018 ua djk||frbm| 00| 0 eng d
040			_aFUE _erda
041			_aeng
082	0	4	_223 _a542.85 _bM.E.A
100	1		_aMorgan, Eman Mohamed, _eauthor.
245	1	2	_aAnalytical Study Of Some Drug Containing Carboxylic Acid Derivatives / _cEman Mohamed Morgan, SupervisorBy, Mohamed Abdel Kawy, Hayam Mahmoud Lotfy, Yasmein Mohamed Fayes..
246			_aدراسة تحليلية على بعض العقاقيرالتي تحتوي على مشتقات مجموعة الكاربوكسيل
264			_c2018.
300			_axxiii, 5, 241 pages. : _billustration. ; _c25 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
502			_aThesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Analytical Chemistry.
504			_aIncludes bibliographical references.
520			_aThis thesis is concerned with the quantitative determination of some drugs containing carboxylic acid derivatives; namely Valaciclovir Hydrochloride and Trimebutine Maleate in their pure powdered form, in presence of their degradation products and application on pharmaceutical formulations. In this thesis; different analytical techniques were adopted, namely, UV-spectrophotometric, visible spectrophotometric, chromatographic and electrochemical methods for the determination of the previously mentioned compounds in their pure powder, laboratory prepared mixtures and pharmaceutical formulations. In part I; General introduction and literature review of valaciclovir hydrochloride (VAL) and its active metabolite aciclovir (ACI) were described. This part described also the quantitative determination of VAL in pure form or dosage form using UV-spectrophotometry including six methods namely, dual wavelength (DW), induced dual wavelength (IDW), ratio difference (RD), constant center coupled with spectrum subtraction spectrophotometric method (CC-SS), the first derivative of the ratio spectra (DD1) and mean centering of ratio spectra (MCR), visible-spectrophotometric method, chromatographic (RP-UPLC method and TLC-densitometry) methods and electrochemical method (ISE). In part II; General introduction and literature review of trimebutine maleate (TM) were described. Then different analytical methods were described for the determination of the studied drugs in their pure form or dosage form including four spectrophotometric methods namely, dual wavelength (DW), second derivative (D2), ratio difference (RD) and constant center coupled with spectrum subtraction spectrophotometric method (CC-SS) and chromatographic (RP-HPLC and TLC-densitometry) methods.
546			_aText in English, abstracts in English and Arabic.
650		0	_aAnalytical chemistry series.
700	1		_aFayez, Yasmin Mohamed, _eSupervisor.
700	1		_aLotfy, Hayam Mahmoud , _eSupervisor.
700	1		_aAbdelkawy, Mohamed, _eSupervisor.
710		2	_aCairo University. _bFaculty of Pharmacy. _bDepartment of Analytical Chemistry.
942			_2ddc _cTHESIS