000			03290cam a22003854i 4500
999			_c11820 _d11820
001			12665132
003			EG-NcFUE
005			20200922121735.0
008			020201s2019 nyua b 001 0 eng
010			_a 2002019330
020			_a9780367396268
020			_a9780824706494
020			_z0824706498 (hbk.; alk. paper)
040			_aDLC _cDLC _dDLC
042			_apcc
050	0	0	_aRM301.25 _b.I565 2002
082	0	0	_a615.19 _221 _bI.
245	0	0	_aIntegrated drug discovery technologies / _cedited by Houng-Yau Mei, Anthony W. Czarnik.
264	1		_aNew York : _bCRC Press, _c2019.
300			_axii, 577 pages : _billustartions (some color) ; _c24 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index.
505	0		_a. The Motivation: A Top-Down View / Wendell Wierenga -- 2. Target Identification and Validation: Coupling Genotype to Phenotype / Gary McMaster -- 3. Functional Genomics / David O'Hagan -- 4. Integrated Proteomics Technologies / Joseph A. Loo, James A. Blackledge and Ping Du / [and others] -- 5. Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications / Tony J. Beugelsdijk -- 6. SNP Scoring for Drug Discovery Applications / John P. Nolan, P. Scott White and Hong Cai -- 7. Protein Display Chips / Tina S. Morris -- 8. Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets / Christian Rohlff -- 9. High-Throughput Screening as a Discovery Resource / John P. Devlin -- 10. Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS[superscript +] plus): Multiple Read-Out Options for Miniaturized Screening / Cornelia Rufenach, Andreas Scheel and Sylvia Sterrer / [and others] -- 11. Homogeneous Time-Resolved Fluorescence / Loraine V. Upham, Jocelyn W. Burke and Betty Howard / [and others] -- 12. ADME-Tox Screening in Drug Discovery / Albert P. Li -- 13. Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells / Kenneth A. Giuliano, Ravi Kapur and Keith R. Olson / [and others] -- 14. Miniaturization Technologies for High-Throughput Biology / Walter D. Niles and Peter J. Coassin -- 15. Data Management for High-Throughput Screening / Lee Amon -- 16. Combinatorial Chemistry: The History and the Basics / Michal Lebl -- 17. New Synthetic Methodologies / Tasir S. Haque, Andrew P. Combs and Lorin A. Thompson -- 18. Supports for Solid-Phase Synthesis / Christophe Fromont, Vincent Pomel and Mark Bradley -- 19. The NMR "Toolkit" for Compound Characterization / Paul A. Keifer -- 20. Materials Management / David A. Kniaz.
650		0	_aDrug development.
650		0	_aHigh throughput screening (Drug development)
650		0	_aCombinatorial chemistry.
700	1		_aMei, Houng-Yau, _d1960-, _eeditor.
700	1		_aCzarnik, Anthony W., _d1957-, _eeditor.
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0647/2002019330-d.html
906			_a7 _bcbc _corignew _d1 _eocip _f20 _gy-gencatlg
942			_2ddc _cBK