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010 _a 2005003235
020 _a047146127X (cloth)
040 _aDLC
_cDLC
_dDLC
042 _apcc
050 0 0 _aRS189.5.S65
_bI55 2005
082 0 0 _a615.19
_222
245 0 0 _aIntegrated strategies for drug discovery using mass spectrometry /
_c[edited by] Mike S. Lee.
264 1 _aHoboken, N.J. :
_bWiley-Interscience,
_c[2005]
300 _axvii, 550 pages :
_billustration ;
_c24 cm
336 _2rdacontent
_atext
337 _2rdamedia
_aunmediated
338 _2rdacarrier
_avolume
505 0 _aMiniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock.
650 0 _aMass spectrometry.
650 0 _aDrugs
_xAnalysis.
650 0 _aHigh throughput screening (Drug development)
700 1 _aLee, Mike S.,
_d1960-
856 4 1 _3Table of contents only
_uhttp://www.loc.gov/catdir/toc/ecip057/2005003235.html
856 4 2 _3Contributor biographical information
_uhttp://www.loc.gov/catdir/enhancements/fy0621/2005003235-b.html
856 4 2 _3Publisher description
_uhttp://www.loc.gov/catdir/enhancements/fy0621/2005003235-d.html
906 _a7
_bcbc
_corignew
_d1
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942 _2ddc
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