000			04950cam a2200373 i 4500
999			_c11874 _d11874
001			17894990
005			20210112112710.0
008			130923s2018 flua bf 001 0 eng
010			_a 2013443454
020			_a9781439860977 (paperback)
040			_aDLC _beng _erda _cDLC _dDLC
042			_apcc
050	0	0	_aQD251.3 _b.L46 2013
082	0	0	_a547.0078 _223 _bL.J.A
100	1		_aLeonard, J. _q(John), _d1954- _eauthor.
245	1	0	_aAdvanced practical organic chemistry / _cJohn Leonard, Barry Lygo, Garry Procter.
250			_aThird edition / _bJohn Leonard, Barry Lygo, Garry Procter.
264		1	_aBoca Raton : _bCRC Press, Taylor & Francis Group, _c[2018]
300			_axxv, 330 pages : _billustrations ; _c24 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aGeneral introduction Safety Safety is your primary responsibility Safe working practice Safety risk assessments Common hazards Accident and emergency procedures Bibliography Keeping records of laboratory work Introduction The laboratory notebook Keeping records of data Some tips on report and thesis preparation References Equipping the laboratory and the bench Introduction Setting up the laboratory General laboratory equipment The individual bench Equipment for parallel experiments Equipment for controlled experimentation Purification and drying of solvents Introduction Purification of solvents Drying agents Drying of solvents References Reagents: Preparation, purification, and handling Introduction Classification of reagents for handling Techniques for obtaining pure and dry reagents Techniques for handling and measuring reagents Preparation and titration of simple organometallic reagents and lithium amide bases Preparation of diazomethane References Gases Introduction Use of gas cylinders Handling gases Measurement of gases Inert gases Reagent gases References Vacuum pumps Introduction House vacuum systems (low vacuum) Medium vacuum pumps High vacuum pumps Pressure measurement and regulation Carrying out the reaction Introduction Reactions with air-sensitive reagents Reaction monitoring Reactions at other than room temperature Driving equilibria Agitation Use of controlled reactor systems References Working up the reaction Introduction Quenching the reaction Isolation of the crude product Data that need to be collected on the crude product prior to purification Purification Introduction Crystallization Distillation Sublimation Flash chromatography Dry-column flash chromatography Preparative TLC Medium pressure and prepacked chromatography systems Preparative HPLC References Small-scale reactions Introduction Reactions at or below room temperature Reactions above room temperature Reactions in NMR tubes Purification of materials Large-scale reactions Introduction Carrying out the reaction Workup and product isolation Purification of the products Special procedures Introduction Catalytic hydrogenation Photolysis Ozonolysis Flash vacuum pyrolysis (FVP) Liquid ammonia reactions Microwave reactions References Characterization Introduction NMR spectra IR spectra UV spectroscopy Mass spectrometry Melting point (m.p.) and boiling point (b.p.) Optical rotation Microanalysis Keeping the data Troubleshooting: What to do when things don’t work The chemical literature The structure of the chemical literature Some important paper-based sources of chemical information Some important electronic-based sources of chemical information How to find chemical information Current awareness References Appendices Properties of common solvents Properties of common gases Approximate pKa values for some common reagents versus common bases Common Bronsted acids Common Lewis acids Common reducing reagents Common oxidizing reagents Index
520			_aWith an emphasis on the most up-to-date techniques commonly used in organic synthesis, this third edition reference draws on the extensive experience of the authors and their association with some of the world' s leading laboratories of synthetic organic chemistry. Written mainly for postgraduate, advanced undergraduate, and industrial organic chemists, this book emphasizes understanding rather than learning facts and offers fully updated information and re-drawn figures to illustrate the information at the highest possible standard. The increased size ...
650		0	_aOrganic compounds _xSynthesis.
650		0	_aChemistry, Organic _vLaboratory manuals.
700	1		_aLygo, B., _eauthor.
700	1		_aProcter, Garry, _eauthor.
906			_a7 _bcbc _corigcop _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK