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008			990202s2019 enka b 001 0 eng c
020			_a9780367399856 (alk. paper)
020			_z9780824702298 (hbk)
040			_aDNLM/DLC _cDLC _dDLC
042			_apcc
082	0	4	_a615.7 _222 _bH.
245	0	0	_aHandbook of drug metabolism / _cedited by Thomas F. Woolf.
264		1	_aLondon : _bCRC Press, _c2019.
300			_axi, 596 pages : _billustrations ; _c26 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references and index.
505	0		_aPart 1 Fundamental Aspects of Drug Metabolism 1. Pharmacokinetics of Drug Metabolites / Philip C. Smith -- 2 Oxidative Metabolic Bioactivation of Xenobiotics /Stéphane Mabic, Kay Castagnoli, and Neal Castagnoli, Jr. -- 3. Morphofunctional Aspects of the Hepatic Architecture: Functional and Subcellular Corelates / Felix A. de la lglesia, Donald G. Robertson, and Jeffrey R. Haskins The Cytochrome P450 Oxidative System / Paul R. Ortiz de Montellano -- 5. Transformation Enzymes: Oxidative: Non-P450 / Allen E. Rettie and Michael B. Fisher Transformation Reactions: Glucuronidation Brian Burchell Part 2 Factors Affecting Drug Metabolism Pharmacogenetics Ann K. Daly -- Inhibition of Drug Metabolizing Enzymes: Molecular und Biochermical F. Peter Guengerich 2. Metabolic Drug Interactions Wayne D. Hooper 10. Induction of Human Drug-Metabolizing Enzymes: Mechanisms and Implications Martin J. J. Ronis and Magnus Ingelman-Sundberg 11 Sites of Metabolism: Lung Garold S. Yost Part 3 Technologies 12 Applications of Heterologous Expressed and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective A. David Rodrigues 13 In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool in Drug Development Thomas Friedberg, C. J. Henderson, M. P. Pritchard, and C. R. Wolf 14 In Vitro Metabolism Subcellular Eractions Sean Ekins, Jukka Mäenpää, and Steven A. Wrighton 15 In Vitro Metabolism Hepatocytes Michael W. Sinz 16 The Isalated PerfusedLiver as a Tool in Drug Mctabolism Studies -- Michael W. SinZ 16 The Isolated Perfused Liver as a Tool in Drug Metabolism Studies Marián Kukan 17 Metabolic Models of Cytotoxicity Munir Pirmohamed and B. Kevin Park 18. In Vitro Metabolism: FMO and Related Oxygenations John R. Cashman 19 Applications of Caco-2 Cells in Drug Discovery and Development Shiyin Yee and Wesley W. Day 20. The Role of Nuclear Magnetic Resonance Spectroscopy in Drug Metabolism 1. D. Wilson, J. K. Nicholson, and J. C. Lindon -- Part 4 Metabolism in Drug Discovery and Development 21. Preclinical Drug Metabolism Studies and Strate gies Philip B. Inskeep and Wesley W. Day 22 Clinical Drug Metabolism Studies William F. Pool.
650		0	_aDrugs _xMetabolism.
650	1	2	_aPharmaceutical Preparations _xmetabolism.
700	1		_aWoolf, Thomas F., _d1955-, _eeditor.
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0647/99017637-d.html
906			_a7 _bcbc _corignew _d1 _eocip _f19 _gy-gencatlg
942			_2ddc _cBK