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008			020417s2002 enka b 001 0 eng d
010			_a 2002280285
015			_aGBA2-Y9890
020			_a9788126547890
020			_z0471496367
020			_z0471496375 (PBK.)
035			_a(OCoLC)ocm48930503
040			_aUKM _cUKM _dDLC
042			_alccopycat
050	0	0	_aRS403 _b.B57 2002
082	0	0	_a615.19 _222 _bB.C.P
100	1		_aBladon, Christine M. _eauthor.
245	1	0	_aPharmaceutical chemistry : _btherapeutic aspects of biomacromolecules / _cChristine M. Bladon.
264		1	_aChichester : _bWiley, _c[2002]
264		3	_aChichester : _bWiley, _c2014
300			_axii, 221 pages : _billustrations ; _c25 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
500			_aTitle page verso: First Printing 2002
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction -- Overview -- Endocrine disorders -- Severe combined immunodeficiency disorders -- Biomacromolecules in the Treatment of Human Disease -- Endogenous Peptides and Proteins -- Overview -- Isolation from Natural Tissues and Fluids II -- Synthesis and Semi-Synthesis -- Peptide synthesis -- Gene Cloning -- Growth hormone -- Transgenic Procedures -- Examples of Direct Replacement Strategy -- Insulin -- The fibrin and fibrinolytic cascades -- Modification of Endogenous Peptides and Protcins -- Overview -- Peptide Mimetics -- Mimetics based on luteinizing hormone-releasing hormone -- Mimetics based on somatostatin -- Chemical Modification of Proteins -- Immunoassays --Modification with synthetic polymers -- Modification of enzyme active sites -- Protein Engineering -- Site-directed mutagenesis -- Chimeric toxins -- Chimeric and humanized antibodies -- The single-chain Fv -- Phage display -- The Immune System Overview -- The Antibody-Mediated Response -- Polyclonal antibodies -- Monoclonal antibodies -- Vaccines -- Hepatitis B vaccine -- Approaches to an HIV vaccine -- The Cell-Mediated Immune Response -- Immunoenhancement II -- Immunosuppression -- Cancer Immunotherapy -- Antibody-mediated immunotherapy -- T-cell-mediated immunotherapy -- Oligonucleotides -- Overview -- Gene Therapy -- Introduction -- Ex vio gene delivery -- Clinical applications -- Antisense Therapy -- Introduction -- Development of an antisense oligonucieotide -- Clinical studies IST -- Oligosaccharides -- Overview -- Oligosaccharide Synthesis -- Heparin -- Glycoproteins -- Blood group oligosaccharides -- Polysaccharide Bacterial Vaccines -- Approaches to Carbohydrate-Based Cancer Vaccines -- Appendix -- A.1 Amino Acids and Peprides A.LI Abbeeviations and structural representations -- Secondary structures -- A.2 Oligonocleotides. DNA and RNA -- Carbohydrates -- index.
650		0	_aPharmaceutical chemistry.
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/description/wiley035/2002280285.html
856	4	1	_3Table of contents _uhttp://www.loc.gov/catdir/toc/wiley022/2002280285.html
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBK